Quantitative Analysis of Serum TGF-β Isoforms in Chronic Periodontitis Patients.

doi:10.13701/j.cnki.kqyxyj.2017.06.010

Abstract

Abstract: Objective: To examine the role of TGF-β isoforms (TGF-β1, TGF-β2 and TGF-β3) in chronic periodontitis. Methods: The research subjects were divided into moderate periodontitis group (n=9), severity periodontitis group (n=18), and healthy controls (n=19). Then their serum was detected through Luminex200 based multi-analytic assay. Results: The levels of serum TGF-β1 (41053.26±8318.65)ng/L and TGF-β3(2454.58±552.73)ng/L in control group were significantly higher than those in moderate periodontitis group (32112.22±7153.87)ng/L, P＜0.01; (1991.11±532.22)ng/L, P＜0.05, respectively and severity periodontitis group (30652.89±8245.31)ng/L, P＜0.01; (1829.17±483.68)ng/L, P＜0.01. TGF-β1 and TGF-β3 were negative correlated with CAL, PD, BOP and PLI. There was a strong positive correlation between TGF-β1 and TGF-β3. Conclusion: Higher concentration of TGF-β1 in serum may have inhibitory effect on the development of chronic periodontitis. TGF-β3 also has a similar inhibitory effect and it maybe interact with TGF-β1.

Key words: Chronic periodontitis , Serum , Luminex multi-analytic assay, TGF-β isoforms

CLC Number:

R781.4

LI Shuang, MENG Xiao-Xue , ZHOU Jian-Ye, YI Gen-Yun , HUANG Hui-Min, ZHANG Xiao-Feng, LI Zhi-Qiang, YU ZHAN Hai.. Quantitative Analysis of Serum TGF-β Isoforms in Chronic Periodontitis Patients.[J]. Journal of Oral Science Research, 2017, 33(6): 618-622.

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