Abstract: Objective: To assess the possible protective effect of platelet-rich fibrin (PRF) against mice impaired wound. Methods: Twenty-one Balb/C mice, who received full thickness skin wound (1.5 cm × 1.5 cm) on the back were obtained. The wound mice were then randomly divided into 3 groups, i.e. skin defect control group, public products in the control group (AD chitin), and freeze-dried PRF particle groups. The healing time and the healing rate of wound in mice were measured in different groups. Skin tissue pathological slices were taken on 21th day and healing condition was observed. Results: On days 21, wound area and volume in freeze-dried PRF particle treatment wounds were significantly decreased compared with those in other groups (P＜0.01).The healing time was shorter than that of other groups. Conclusion: These results confirmed that PRF had potential to accelerate the speed and improve the quality of open wound healing of skin. It provides a new strategy to promote skin wound repair after injury.

Key words: Platelet-rich fibrin, Cutaneous full-thickness wound, Wound healing