Expression and Clinical Significance of Rab38 in Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2017.09.009

Abstract

Abstract: Objective: To investigate the expression of Rab38 in oral squamous cell carcinoma and its clinical significance. Methods: Rab38 mRNA expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR) in 60 matched OSCC and adjacent non-tumorous tissues. Expression of Rab38 was evaluated by immunohistochemistry in 149 cases of OSCC and matched adjacent non-tumorous tissues. Relationships between protein expression level and clinicopathological parameters were evaluated. Results: Rab38 was over-expressed in OSCC tissues. Clinical analysis indicated that high expression of Rab38 was obviously associated with TNM stage and lymph node metastasis. OSCC patients with high levels of Rab38 expression had shorter overall survival (OS). Multivariate cox regression analysis demonstrated that Rab38 expression remained an independent prognosis. Conclusion: Overexpression of Rab38 is closely related to poor prognosis. Rab38 may contribute to the development of OSCC, and may be used as a biomarker for evaluating outcomes.

Key words: Rab38, OSCC , Prognosis

CLC Number:

R739.8

ZHENG Zheng, HE Ying-yang, XIE Di-ya, CHEN Yan, WANG Ze-zheng, HAO Feng-yao, WANG Zhi-yong. Expression and Clinical Significance of Rab38 in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2017, 33(9): 946-949.

References

[1] 陈震,郭燕.E-cadherin和Vimentin在OSCC上皮-间质转化中的作用及表达[J].口腔医学研究,2016,32(8)∶857-860
[2] L r E, Korpi JT, Pitk nen H, et al. Competing risks analysis of cause-specific mortality in patients with oral squamous cell carcinoma [J]. Head & neck, 2016,39(5)∶587-594
[3] Petti S, Masood M, Scully C. The Magnitude of Tobacco Smoking-Betel Quid Chewing-Alcohol Drinking Interaction Effect on Oral Cancer in South-East Asia. A Meta-Analysis of Observational Studies [J]. PloS one, 2013, 8(11)∶e78999
[4] Marubashi S, Shimada H, Fukuda M, et al. RUTBC1 Functions as a GTPase-acitvating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes [J]. Journal of Biological Chemistry, 2016, 291(3)∶1427-1433
[5] Abdel-Monsef AH, Dulapalli R, Dasari T, et al. Identification of novel antagonists for Rab38 protein by homology modeling and virtual screening [J]. Combinatorial chemistry & high throughput screening, 2016, 19(999)∶437-446
[6] Wang H, Jiang C. RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma [J]. Oncology reports, 2013, 30(5)∶2350-2356
[7] Wu CE, Wang CW, Huang WK, et al. Cytoplasmic and nuclear parathyroid hormone-related proteins are opposing prognostic factors in patients with non-small-cell lung cancer who have undergone curative resection [J]. Japanese Journal of Clinical Oncology, 2015, 45(3)∶267-272
[8] Ciniselli CM, Volpi CC, Cortelazzi B, et al. Reproducibility between mRNA RT-PCR and mRNA ISH in OSCC patients [J]. Human pathology, 2015, 47(4)∶562-569
[9] Nayak S, Goel MM, Makker A, et al. Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma [J]. PloS one, 2015,10(10)∶e0138801
[10] 李宠,朱杨,山本哲也,等.口腔鳞癌细胞分泌的胞外体对其生物学行为的影响[J].口腔医学研究,2016,32(8)∶800-803
[11] Vuruputuri U, Abdelmonsef AH, Dulapalli R, et al. Structure based drug discovery of Rab38 protein- Identification of antagonists as cancer drug candidates [J]. Combinatorial chemistry & high throughput screening, 2016,19(999)
[12] Scheilbertram S, Kappler R, Baer AV, et al. Molecular profiling of chordoma [J]. International journal of oncology, 2014, 44(4)∶1041-1055
[13] McGill MR, Jaeschke H. MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury [J]. Journal of Clinical Medicine, 2015, 4(5)∶1063-1078
[14] Liu Q, Tang H, Liu X, et al. miR-200b as a prognostic factor targets multiple members of RAB family in glioma [J]. Medical oncology, 2014, 31(3)∶859-866
[15] Tzeng HT, Wang YC. Rab-mediated vesicle trafficking in cancer [J]. Journal of biomedical science, 2016, 23(1)∶70-78