Serum Cytokine Response to Periodontal Infection in Overweight Mice

doi:10.13701/j.cnki.kqyxyj.2018.06.017

Abstract

Abstract: Objective: To explore systemic immune response of overweight host to periodontal infection. Methods: Twenty-eight C57 BL/6J mice were divided into high-(HFD) or low-fat diet (LFD) groups to induce overweight or being as controls, respectively. After 8 weeks on diet, both two diet groups were subdivided into periodontitis (P) or periodontal-health controls (C) (n=7), with the P group for periodontal ligation and the C group as controls. The mice were killed after 10 days’ ligation. Linear bone loss fraction was analyzed by micro-CT. Twenty candidate serum cytokines were detected by protein arrays. Differences between the four groups were analyzed by one-way ANOVA. Results: The HFD group had 3.8g or 15.5% higher body weight than that of the LFD group (P<0.01). The P group had significantly higher linear bone loss fraction compared with that of the C group (P<0.01). Except for IL-6, the level of which was significantly higher in the HFDP group relative to the LFDC group (P<0.05), no any other serum cytokines showed significantly different levels between HFD and LFD groups or between P and C groups within the HFD mice. Conclusion: No significant mediating role of systemic inflammation is found in correlation between overweight and periodontitis.

Key words: Obesity, Overweight, Periodontal diseases, Inflammation, Cytokine

YU Ting, ZHAO Li, ZHANG Jin-cai, XUAN Dong-ying. Serum Cytokine Response to Periodontal Infection in Overweight Mice[J]. Journal of Oral Science Research, 2018, 34(6): 644-647.

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