Research Progress and Application Potential of Photodynamic Therapy in Treating Oral Candidiasis

doi:10.13701/j.cnki.kqyxyj.2020.12.002

Abstract

Abstract: Photodynamic therapy (PDT) is a precision targeted therapy that produces singlet oxygen through photodynamic reaction to exert selectively anti-tumor and anti-microbial activity. With the broadened clinical application in recent years, PDT's anti-candida effect has attracted more attention. Compared with traditional antifungal agents, PDT has relatively definite mechanism and curative effect, and does not lead to resistance, which exhibits clinical potential in the treatment of oral candidiasis. Here we conduct a comprehensive review of the current knowledge of mechanisms, influence factors, clinical effectiveness and safety, research progress, and application potential of PDT in treating oral candidiasis.

Key words: photodynamic therapy, oral candidiasis, effectiveness, safety

WEI Diyuan, YAN Zhimin. Research Progress and Application Potential of Photodynamic Therapy in Treating Oral Candidiasis[J]. Journal of Oral Science Research, 2020, 36(12): 1087-1090.

References

[1] Jeffery-Smith A, Taori SK, Schelenz S, et al. Candida auris: a review of the literature [J]. Clin Microbiol Rev, 2018, 31(1):e00029-17.
[2] Rabb O. Uber die wirkung fluoreszierender stoffe auf infusorien [J]. Z Biol, 1900, 39: 524-546.
[3] Baltazar LM, Ray A, Santos DA, et al. Antimicrobial photodynamic therapy: an effective alternative approach to control fungal infections [J]. Front Microbiol, 2015, 6:202.
[4] Donnelly RF, Mccarron PA, Tunney MM. Antifungal photodynamic therapy [J]. Microbiol Res, 2008, 163(1):1-12.
[5] Kashef N, Hamblin MR. Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation [J]. Drug Resist Updat, 2017, 31:31-42.
[6] Liyi H, Brijesh B, Weijun X, et al. Comparison of two functionalized fullerenes for antimicrobial photodynamic inactivation: Potentiation by potassium iodide and photochemical mechanisms [J]. J Photochem Photobiol B, 2018, 186:197-206.
[7] Freire F, Ferraresi C, Jorge AO, et al. Photodynamic therapy of oral Candida infection in a mouse model [J]. J Photochem Photobiol B, 2016, 159:161-168.
[8] Prates RA, Kato IT, Ribeiro MS, et al. Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans [J]. J Antimicrob Chemother, 2011, 66(7):1525-1532.
[9] Teichert MC, Jones JW, Usacheva MN, et al. Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 93(2):155-160.
[10] Mima EG, Pavarina AC, Silva MM, et al. Denture stomatitis treated with photodynamic therapy: five cases [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(5):602-608.
[11] Abduljabbar T, Al-Askar M, Baig MK, et al. Efficacy of photodynamic therapy in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis [J]. Photodiagnosis Photodyn Ther, 2017, 18:50-53.
[12] Mima EG, Vergani CE, Machado AL, et al. Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial [J]. Clin Microbiol Infect, 2012, 18(10):E380-E388.
[13] de Senna AM, Vieira MMF, Machado-De-Sena RM, et al. Photodynamic inactivation of, Candida, ssp. on denture stomatitis: A clinical trial involving palatal mucosa and prosthesis disinfection [J]. Photodiagnosis Photodyn Ther, 2018, 22: 212-216.
[14] Maciel CM, Piva MR, Ribeiro MA, et al. Methylene blue-mediated photodynamic inactivation followed by low-laser therapy versus miconazole gel in the treatment of denture stomatitis [J]. J Prosthodont, 2016, 25(1):28-32.
[15] Scwingel AR, Barcessat AR, Núñez SC, et al. Antimicrobial photodynamic therapy in the treatment of oral candidiasis in HIV-infected patients [J]. Photomed Laser Surg, 2012, 30(8):429-432.
[16] 全昌园.抗菌光动力疗法(APDT)对AIDS合并口腔白色念珠菌病临床疗效观察[D].南宁:广西医科大学,2017.
[17] 赵玥,覃金梅,黄力毅.二甲基蓝介导的光动力抗菌疗法对AIDS合并口腔白色念珠菌病的疗效观察[J].广西医科大学学报,2018,35(2):178-180.
[18] 覃金梅.光动力疗法对AIDS患者口腔白色念珠菌病的抗菌效应研究[D].南宁:广西医科大学,2018.
[19] Teichert MC, Jones JW, Usacheva MN, et al. Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 93(2):155-160.