Advances in Regulation of Macrophage Behaviors by Nanomaterials for Promoting Bone Regeneration

doi:10.13701/j.cnki.kqyxyj.2022.11.002

Abstract

Abstract: Bone defects and osteopenia are common diseases. Macrophages are an important kind of innate immune cells, which participate in bone healing and regeneration. As macrophages have high plasticity, they become the crucial targets during the osteoimmunomodulation of bone biomaterials. Currently, by regulating immune cells such as macrophages through nanostructures to promote bone regeneration has reached some achievements. In this review, we summarize the studies on the regulation of macrophages to promote bone regeneration via chemical compositions, surface structures, and carried-bioactive molecules of nanostructures, in order to provide new ideas for the clinical treatments of bone defects and osteopenia.

Key words: nanostructures, bone regeneration, macrophages, osteoimmunomodulation

LI Chang, YIN Chengcheng. Advances in Regulation of Macrophage Behaviors by Nanomaterials for Promoting Bone Regeneration[J]. Journal of Oral Science Research, 2022, 38(11): 1010-1013.

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