Current Concepts in Mechanical Stimuli on Bone Remodeling

Abstract

Abstract: A wide range of researches have demonstrated that mechanical stimuli play an important role in bone formation and remodeling. Osteoclasts, osteoblasts and osteocytes are able to perceive external mechanical stimuli through various sensors such as integrins, focal adhesion and cadherin, and then activate downstream signaling pathways including MAPK pathways, β-catenin pathways, and GTPase cascades, to affect the development and metabolism of bone tissue. This review intends to expound recent progress in this field, of signaling pathways related to mechanical stimuli.

Key words: Remodeling, Mesenchymal stem cells, Mechanical stimuli, Sensors, Signaling pathways

CLC Number:

R318.01

WANG Zhu-yu, ZHANG Xiao-lei. Current Concepts in Mechanical Stimuli on Bone Remodeling[J]. Journal of Oral Science Research, 2015, 31(10): 1050-1052.

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