Study on Degradation and Biological Compatibility of PGS/PLLA Electrospuning Films.

doi:10.13701/j.cnki.kqyxyj.2016.05.001

Abstract

Abstract: Objective: To explore the feasibility of the poly-glycerol-sebacate/poly-l-lactic acid (PGS/PLLA) electrospuning film as a scaffold of goat TMJ disc tissue engineering by assessing the degradation and cytocompatibility in vitro. Methods: The morphological features, weight loss, pH value changes in the PBS, and the mechanical properties of the PGS/PLLA electrospuning films were evaluated during the degradation process. Moreover, the TMJ disc cells were co-cultured with the PGS/PLLA scaffold and the biocompatibility was assessed by MTT assays. Finally, the hematoxylin-eosin staining, safranin O staining and immunohistochemistry staining were tested on the 14^th day. Results: The PGS/PLLA electrospuning films showed proper degradation performance. Nontoxic properties and favorable cell proliferation were observed. Conclusion: TMJ disc cells can adhesive and proliferate on the PGS/PLLA scaffold. The PGS/PLLA can serve as a potential scaffold to repair the TMJ disc disease.

CLC Number:

R782.6

ZHONG Ni,BAO Guangjie, LI Yan-mei, LV Wei, ZHANG Wen-xia, ZHAO Hong-bin,KANG Hong.. Study on Degradation and Biological Compatibility of PGS/PLLA Electrospuning Films.[J]. Journal of Oral Science Research, 2016, 32(5): 427-431.

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