Journal of Oral Science Research ›› 2016, Vol. 32 ›› Issue (7): 712-715.DOI: 10.13701/j.cnki.kqyxyj.2016.07.012

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Salivary Duct Carcinoma: A Clinical Analysis of 10 Cases.

KEREMU Abasi, CHEN Qing-li, LING Bin, LIU Hui, LIN Zhao-quan, GONG Zhong-cheng*.   

  1. Oncological Department of Oral and Mxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
  • Received:2015-12-01 Online:2016-07-26 Published:2016-07-25

Abstract: Objective: To evaluate the clinical manifestation, treatment and prognosis of patients with salivary duct carcinoma (SDC). Methods: Clinical data of 10 patients with SDC from Oct. 2007 to Nov. 2014 were collected and retrospectively analyzed. Results: In this study, the included patients with SDC (8 male and 2 female) were aged from 49 years to 89 years with mean age 64.7 years. With 8 cases of parotid gland and 2 cases of submandibular gland, the patients presented regional mass characterized by recent rapid growth and neural impairment. CT images revealed the mass with ill-defined margin and inhomogeneous enhancement. For the treatment, only six patients received post-operative radiotherapy. Follow-up period was 7 months to 97 months. Three patients recurred. The median survival time was 37.5 months. The 1-, 3-, 5-year disease-free survival rates of these 10 patients with SDC were 90% (95% CI: 55-100), 62.5% (95% CI: 24-91) and 57.1% (95% CI: 18-90), respectively. Conclusion: SDC was a rare disease. The clinical manifestation and imaging examination were not outstanding, while pathological report could guide diagnosis. With poor prognosis, surgery was the first choice and post-operative radiotherapy should be performed. Biological therapy might be a novel treatment strategy for SDC.

Key words: Duct carcinoma , Salivary gland neoplasms , Clinical analysis

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