Expression of LC3B in Local Tissues and T Cells of Oral Lichen Planus.

doi:10.13701/j.cnki.kqyxyj.2016.12.008

Abstract

Abstract: Objective: To investigate the expression level of autophagy-related protein LC3B in local tissues and T cells of oral lichen planus (OLP). Methods: The expression of autophagy-related protein LC3B in OLP local tissues and T cells was investigated by immunohistochemistry and multi-color immunofluorescence staining, respectively. In addition, the associations between LC3B and the clinical features of OLP were analyzed. Results: The expression of LC3B in OLP local tissues and T cells was significantly increased compared with that in controls (P<0.001, P<0.01, respectively), and was negatively correlated with the RAE scores of OLP patients (P<0.05, P<0.01, respectively). Besides, the expression of LC3B in nonerosive OLP tissues was higher than that in erosive OLP tissues (P<0.01). Conclusion: LC3B may participate in the local immunopathogenesis of OLP.

Key words: Oral, lichen planus, LC3B Tissues, T cells, Expression

CLC Number:

R758.65

ZHANG Na, ZHANG Jing, TAN Ya-qin, DU Ge-fei, LU Rui, ZHOU Gang. Expression of LC3B in Local Tissues and T Cells of Oral Lichen Planus.[J]. Journal of Oral Science Research, 2016, 32(12): 1257-1260.

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