Expression of E-cadherin mRNA in the Rat Tongue Carcinogenesis.

doi:10.11839/kqyxzh.2016.01.008

Abstract

Abstract: Objective: To investigate the expression and significance of E-cadherin mRNA in the rat tongue carcinogenesis. Methods: 4NQO Drinking Water Act was used to induce tongue squamous cell carcinoma of rat. The mRNA expression level of E-cadherin was analyzed by q-RT-PCR. Results: The mRNA expression of E-cadherin was down-regulated in the rat tongue carcinogenesis. In the epithelial hyperplasia tissues, mild epithelial dysplasia tissues, moderate to severe epithelial dysplasia tissues and squamous cell carcinoma tissues, E-cadherin mRNA level was 0.453541, 0.207062, 0.190954, 0.180987 times by the normal epithelial tissues, respectively. The differences between squamous cell carcinoma group and normal epithelial group were statistically significant (P＜0.05). Conclusion: With the increase of pathological grade, E-cadherin mRNA expression showed a decreasing trend. The change of E-cadherin mRNA expression was an early event in rat tongue mucosa carcinogenesis.

CLC Number:

R739.8

TAN Hong, MAO Liang, WANG Min, LIAO Peng-cheng, NIE Min-hai.. Expression of E-cadherin mRNA in the Rat Tongue Carcinogenesis.[J]. Journal of Oral Science Research, 2016, 32(1): 31-34.

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