Abstract: Objective: To study the stress distribution of nano-hydroxyapatite/polyetheretherketone (n-HA/PEEK) bionic implant and the alveolar bone surrounding the implant, and to provide biomechanical basis for clinical application of the implant. Methods: According to CT scan and implant product data, a three-dimensional finite element model with a implant and its surrounding alveolar bone was set up. The stress distributions of cortical bone and cancellous bone surrounding both n-HA/PEEK and titanium implants were compared when bearing vertical loading of 150 N. Results: The stresses of the cortical for the two implants were the largest at the implant necks, and decreased as the bone cortex got away from the neck. In the cortical bone there are significant differences between the maximum stress on the surface of the two implants (P<0.05). The range of stress fluctuation on the load-bearing titanium implant surface increased,and it was prone to form stress concentration. The surface stress of n-HA/PEEK materials, which shared similar elastic modulus with bone tissue, distributed more uniformly. Conclusion: N-HA/PEEK material is more conducive to transfer the load to the surrounding bone tissue in the form of stress, which is helpful to maintain the long-term stability of implant and bone interface.