Abstract: Objective: To assess the osseointegration of porous titania (TiO2) coating with a novel cortex-like morphology by micro-CT. Methods: Cortex-like morphology Ti surface was produced by MAO, and SLA surface was used as control.The surface features were evaluated by scanning electron microscope (SEM) and contact Angle. Thirty-six threaded implants were placed in the femoral condyles of 18 male New Zealand White rabbits. Trabecular bone morphology parameters were analyzed after implantation 4 weeks and 8 weeks by Micro-CT. Results: Morphology microstructure of MAO cortex-like was composed of microscale and nanoscale structure, with better wettability and contact Angle (6.9±1.14)°. Along with the time of bone healing, the BV/TV, Tb. N, Tb. Th and Conn. Dn were increased, while SMI and Tb. Sp were decreased. At 4th week, statistical significances were detected in BV/TV and SMI (P<0.05). At 8th week, statistical significances were detected in BV/TV, Tb. N, Tb. Sp and Conn.Dn (P<0.05). Cortex-like morphology exhibited more continuous bone apposition. Conclusion: The cortex-like morphology of titanium with microscale and nanoscale topologic structure can improve the osseointegration of Ti implant and has good biocompatibility.

Key words: Titanium implant , Micro-arc oxidation , Cortex-like morphology, Micro-CT, Trabecnlav