Journal of Oral Science Research ›› 2019, Vol. 35 ›› Issue (6): 517-520.DOI: 10.13701/j.cnki.kqyxyj.2019.06.002

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Research Progress on Biomimetic Enamel Mineralization Induced by Proteins and Peptides from Oral Cavity.

HU Die, ZHANG Ling-lin*   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
  • Received:2018-06-05 Online:2019-06-28 Published:2019-06-27

Abstract: During enamel biomineralization, ameloblasts secrete proteins to mediate the hydroxyapatite crystallites to form the well-organized prism pattern. Finally, a highly complex and ordered enamel structure is formed. When the enamel is destructed, it is of great difficulties and high popularity to find biomimetic reparative materials or methods that can induce the regeneration of enamel microstructure at present. Among them, enamel biomimetic mineralization using proteins derived from oral environment and their derived peptides is a promising way to rebuild the enamel. In this paper, we review the advancement of enamel biomimetic mineralization induced by proteins and their derived peptides from oral cavity according to the latest reports in recent years.

Key words: Enamel, Protein, Peptide, Biomimetic mineralization