Research Progress of Endothelial Mesenchymal Transition in Tumors

doi:10.13701/j.cnki.kqyxyj.2019.11.004

Abstract

Abstract: Endothelial-mesenchymal transition (EndMT) means that endothelial cells acquire mesenchymal-like phenotype after stimulated by inflammatory factors. EndMT is not only involved in embryonic development and organ fibrosis, but also has an important impact on the occurrence and development of tumors. This article reviews the effects and mechanisms of EndMT on tumor in recent years in order to provide new ideas and targets for tumor treatment.

Key words: endothelial-mesenchymal transition, cancer, cancer-associated fibroblasts

LIU Xinchen, SUN Hongchen. Research Progress of Endothelial Mesenchymal Transition in Tumors[J]. Journal of Oral Science Research, 2019, 35(11): 1023-1025.

References

[1] Medici D, Kalluri R. Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype [J]. Semin Cancer Biol, 2012, 22(5-6): 379-384.
[2] Laurent F, Girdziusaite A, Gamart J, et al. HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development [J]. Cell Rep, 2017, 19(8): 1602-1613.
[3] Li Y, Lui KO, Zhou B. Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases [J]. Nat Rev Cardiol, 2018, 15(8): 445-456.
[4] Evrard SM, Lecce L, Michelis KC, et al. Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability [J]. Nat Commun, 2016, 7:11853.
[5] Kalluri R. The biology and function of fibroblasts in cancer [J]. Nat Rev Cancer, 2016, 16(9): 582-598.
[6] Shi Y, Du L, Lin L, et al. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets [J]. Nat Rev Drug Discov, 2017, 16(1): 35-52.
[7] Zeisberg EM, Potenta S, Xie L, et al. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts [J]. Cancer Res, 2007, 67(21): 10123-10128.
[8] Welch-Reardon KM, Ehsan SM, Wang K, et al. Angiogenic sprouting is regulated by endothelial cell expression of Slug [J]. J Cell Sci, 2014, 127(Pt 9): 2017-2028.
[9] Huang M, Liu T, Ma P, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma [J]. J Clin Invest, 2016, 126(5): 1801-1814.
[10] Gasparics á, Rosivall L, Krizbai IA, et al. When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition [J]. Am J Physiol Heart Circ Physiol, 2016, 310(9): H1055-H1063.
[11] Mahmoud MM, Serbanovic-Canic J, Feng S, et al. Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail [J]. Sci Rep, 2017, 7(1): 3375.
[12] Krizbai IA, Gasparics Á, Nagyöszi P, et al. Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation [J]. PLoS One, 2015, 10(3): e0123845.
[13] Ou J, Peng Y, Deng J, et al. Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition [J]. Carcinogenesis, 2014, 35(7): 1661-1670.
[14] Ghiabi P, Jiang J, Pasquier J, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche [J]. J Transl Med, 2015, 13:27.
[15] Pérez L, Munoz-Durango N, Riedel CA, et al. Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions [J]. Cytokine Growth Factor Rev, 2017, 33:41-54.
[16] Liu X, Mujahid H, Rong B, et al. Irisin inhibits high glucose-induced endothelial-to-mesenchymal transition and exerts a dose-dependent bidirectional effect on diabetic cardiomyopathy [J]. J Cell Mol Med, 2018, 22(2): 808-822.
[17] Takada S, Hojo M, Tanigaki K, et al. Contribution of endothelial-to-mesenchymal transition to the pathogenesis of human cerebral and orbital cavernous malformations [J]. Neurosurgery, 2017, 81(1): 176-183.
[18] Zhou Z, Tang AT, Wong WY, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling [J]. Nature, 2016, 532(7597): 122-126.
[19] Gong F, Zhao F, Gan XD. Celastrol protects TGF-beta1-induced endothelial-mesenchymal transition [J]. J Huazhong Univ Sci Technolog Med Sci, 2017, 37(2): 185-190.
[20] Farrar EJ, Butcher JT. Heterogeneous susceptibility of valve endothelial cells to mesenchymal transformation in response to TNFalpha [J]. Ann Biomed Eng, 2014, 42(1): 149-161.
[21] Mahler GJ, Farrar EJ, Butcher JT. Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells [J]. Arterioscler Thromb Vasc Biol, 2013, 33(1): 121-130.
[22] Landskron G, De la Fuente M, Thuwajit P, et al. Chronic inflammation and cytokines in the tumor microenvironment [J]. J Immunol Res, 2014, 2014:149185.
[23] Romero LI, Zhang DN, Herron GS, et al. Interleukin-1 induces major phenotypic changes in human skin microvascular endothelial cells [J]. J Cell Physiol, 1997, 173(1): 84-92.
[24] Rieder F, Kessler SP, West GA, et al. Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis [J]. Am J Pathol, 2011, 179(5): 2660-2673.
[25] Storr SJ, Safuan S, Ahmad N, et al. Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro [J]. Cancer Immunol Immunother, 2017, 66(10): 1287-1294.
[26] Honda T, Yamamoto I, Inagawa H. Angiogenesis-, metastasis- and signaling pathway-related factor dynamics in human colon cancer cells following interaction with monocytes [J]. Anticancer Res, 2013, 33(7): 2895-2900.
[27] Echeverría C, Montorfano I, Sarmiento D, et al. Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells [J]. J Cell Mol Med, 2013, 17(6): 800-814.
[28] Liu T, Ma W, Xu H, et al. PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma [J]. Nat Commun, 2018, 9(1): 3439.