Development of Biomimetic Micro/Nano Hierarchical Interface for Enhancement of Osseointegration

doi:10.13701/j.cnki.kqyxyj.2021.04.019

Abstract

Abstract: Objective: To investigate a biomimetic micro/nano hierarchical interface to enhance osseointegration. Methods: The pure titanium samples were modified by three surface treatment methods, namely spark plasma sintering, electrochemical anodization, and composite treatment, which formed Micro-Ti, Nano-Ti and Micro/Nano-Ti structure, respectively. Forty female SD rats were randomly assigned into four groups (Group A, B, C, and D, n=10 animals per group). Bone defects in the diameter of 1.5mm were established on the medial side of the knee joint and inserted with untreated-Ti, Micro-Ti, Nano-Ti, and Micro/Nano-Ti, respectively. Twelve weeks following implantation, the rats were sacrificed and the proximal tibiaes (together with the titanium implants) were harvested for histological analysis, Micro-CT evaluation, and biomechanical testing. Results: Group D had the highest percent of osseointegration, percent bone volume, and bone volume. Multiple relative parameters of trabeculae of group D were relatively high. The compression force and ultimate shear strength of group D were significantly higher than those of the other three groups (P<0.05). Conclusion: Biomimetic micro/nano hierarchical interface enhanced the osseointegration of titanium implants.

Key words: micro/nano hierarchical interface, osseointegration, implants, titania nanotubes, composite treatment

SHI Ziwen, ZHU Songsong, JIANG Nan. Development of Biomimetic Micro/Nano Hierarchical Interface for Enhancement of Osseointegration[J]. Journal of Oral Science Research, 2021, 37(4): 366-370.

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