Research Progress of Mesenchymal Stem Cell-derived Exosomes in Temporomandibular Joint Osteoarthritis

doi:10.13701/j.cnki.kqyxyj.2022.06.005

Abstract

Abstract: Temporomandibular joint osteoarthritis is a degenerative disease characterized by progressive cartilage degeneration, subchondral bone remodeling, synovitis, and chronic pain. Exosomes are membrane vesicles about 30-140 nm in size. They can fuse with adjacent cell membranes to transfer information between different cells and mediate information exchange between cells. They play an important role in regenerative medicine. The nutritional regulation of mesenchymal stem cells has anti-inflammatory and immunomodulatory effects. Mesenchymal stem cell-derived exosomes can mimic the main therapeutic effects of mesenchymal stem cells, and have multi lineage differentiation potential, including cartilage differentiation and osteogenic differentiation. This article reviews the role of mesenchymal stem cell-derived exosomes in the treatment of temporomandibular joint osteoarthritis.

Key words: temporomandibular joint, osteoarthritis, mesenchymal stem cells, exosomes

XU Zejun, MAN Cheng. Research Progress of Mesenchymal Stem Cell-derived Exosomes in Temporomandibular Joint Osteoarthritis[J]. Journal of Oral Science Research, 2022, 38(6): 509-512.

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