Expression and Clinical Significance of Osteoglycin in Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2026.03.011

Abstract

Abstract: Objective: To investigate the expression of osteoglycin (OGN) in oral squamous cell carcinoma (OSCC) tissues and analyze its correlation with patients' clinical pathological characteristics and survival prognosis. Methods: Eighty cases of OSCC paraffin tissue specimens were selected. Immunohistochemistry was used to detect OGN protein expression levels and evaluate the relationship between its expression and clinical pathological characteristics of patients. Kaplan-Meier method was used to evaluate the relationship between OGN expression and prognosis of patients. The correlation between OGN and protein kinase B (AKT1) et al. gene expression was analyzed by cBioPortal database. Results: OGN expression was significantly higher in OSCC than in adjacent normal tissue, mainly localized in tumor cells, and was higher in invasive tumor front than in the tumor center. High OGN expression was associated with later TNM stage, higher T stage, and lymph node metastasis rate (P<0.05), accompanied by a higher Ki-67 positivity rate, and decreased overall survival rate in patients (P<0.05). OGN was positively correlated with epithelial-mesenchymal transition molecules, such as AKT1, mammalian target of rapamycin (mTOR), and vimentin (VIM). Conclusion: OGN is overexpressed in OSCC, and its high expression indicates poor prognosis of patients.

Key words: oral squamous cell carcinoma, osteoglycin, clinical pathological features, prognosis

HE Yijia, ZHANG Xinwen, WANG Zezheng, LI Zihui, DING Liang, WANG Zhiyong. Expression and Clinical Significance of Osteoglycin in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2026, 42(3): 235-241.

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