Effect of P. gingivalis on Chemoresistance of Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2024.05.007

Abstract

Abstract: Objective: To investigate the abundance of porphyromonas gingivalis (P. gingivalis) in oral squamous cell carcinoma (OSCC) and its effect on chemoresistance during chemotherapy. Methods: The expression of P. gingivalis in 67 patients with oral squamous cell carcinoma was detected by in situ hybridization. The cytotoxicity of chemotherapeutic drugs in P. gingivalis infected OSCC was detected by cell counting kit-8 (CCK-8) assay. The expression of drug resistant protein in oral squamous cell carcinoma cells after P. gingivalis infection was detected by Western blot assay. Results: The content of P. gingivalis in OSCC epithelial tissues was higher than that in normal oral epithelial tissues. P. gingivalis infection reduced the killing effect of paclitaxel on OSCC (P<0.05). The expression of P-gp was much elevated after P. gingivalis infection. Conclusion: The high level of P. gingivalis in tumor tissues of patients with oral squamous cell carcinoma may be positively correlated with chemoresistance of OSCC.

Key words: Porphyromonas gingivalis, oral squamous cell carcinoma, chemotherapy, drug resistance

PANG Xiaochan, CHEN Qingli, LUO Guofeng, SHANG Zhengjun. Effect of P. gingivalis on Chemoresistance of Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2024, 40(5): 413-416.

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