Effect of Estrogen Deficiency on the Expression of TLR4 in Periapical Lesions of Rats

Abstract

Abstract: Objective: To investigate the effects of estrogen deficiency on the expression of TLR4 in periapical lesions of rats. Methods: Thirty female rats were randomly divided into 2 groups: OVX group and SHAM group. The pulp cavities of mandibular first molars of rats were exposed. The rats were sacrificed at 0, 7, 14 and 21days after the exposure. Histologic examination for periapical bone loss area, enzyme histochemical examination for tartrate-resistant acid phosphatase (TRAP), and immunohistochemical examination for TLR4 were performed. Results: The alveolar bone loss area, osteoclasts number, and the expression of TLR4 in OVX group were higher than those of SHAM group. Conclusion: Estrogen deficiency increased the expression of TLR4 in the periapical lesions of rats.

Key words: Estrogen deficiency, Osteoclasts, TLR4, Periapical lesions

CLC Number:

R781.3

GUAN Xiao-yue, QIAN Hua, Bian Zhuan. Effect of Estrogen Deficiency on the Expression of TLR4 in Periapical Lesions of Rats[J]. Journal of Oral Science Research, 2015, 31(8): 755-.

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