Correlation between Chronic Periodontitis and Levels of IL-6 as well as IL-17 in Serum and Saliva from Kazak in Mulei, Xinjiang, China

Abstract

Abstract: Objective: To investigate interleukin 17 (IL-17) and interleukin 6 (IL-6) levels in serum and saliva of patients with chronic periodontitis from Kazak, and their correlation with the clinical periodontal index. Methods: A total of 292 subjects from Kazak were included in this study (192 patients with chronic periodontitis and 100 clinically healthy subjects). Five milliliter non-stimulated saliva and serum samples were collected. Enzyme linked immunosorbent assay (ELISA) kit was employed to determine the levels of IL-17 and IL-6. Results: Concentrations of IL-6 and IL-17 in saliva were significantly higher than those in serum from the same patient with chronic periodontitis. There was a moderately positive correlation between concentrations of IL-6 and IL-17 in saliva. Additionally, both their levels showed a positive correlation with the severity of chronic periodontitis. Conclusion: The saliva levels of IL-6 and IL-17 showed significantly increased expression in Kazak patients with chronic periodontitis and were associated with the severity of disease. This suggests that saliva IL-6 and IL-17 levels may be used as indicators of chronic periodontitis in patients from Kazak.

Key words: Chronic periodontitis, Interleukin 17, Interleukin 6, Kazak

CLC Number:

R781.4

SONG Qian, LIU Hua, ZHONG Liang-jun, et al. Correlation between Chronic Periodontitis and Levels of IL-6 as well as IL-17 in Serum and Saliva from Kazak in Mulei, Xinjiang, China[J]. Journal of Oral Science Research, 2015, 31(8): 827-.

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