Abstract: Objective: To investigate the feasibility of modified marginal resection of mandible remaining its continuity with combined radical neck dissection in the surgical management of tongue squamous cell carcinoma. Method: Modified marginal resection of mandible remaining its continuity with combined radical neck dissection was used in 137 cases of tongue squamous cell carcinoma. In the modification group, slice cut and selective grinding of bone between inner inferior border of mandible and mucosa of floor of mouth were added. Selective/radical neck dissection was applied. 30-month follow-up was conducted at least. Results: The median follow-up time was 42 months. Three- or five-year survival rate was 74.45% (101/137) and 70.80% (97/137), respectively. Mastication, swallowing, speech and appearance of all the cases were significantly improved. The curative effect was satisfactory. Conclusion: Modified marginal resection of mandible remaining its continuity with combined radical neck dissection is feasible in the treatment of tongue squamous cell carcinoma.