Detection of Th17 and Related Factors in Gingival Crevicular Fluid of Patients with Different Periodontal Inflammatory Status

doi:10.13701/j.cnki.kqyxyj.2017.11.007

Abstract

Abstract: Objective: To study the correlation of Th17 and related factors in the gingival crevicular fluid (GCF) of the patients with different periodontal inflammatory status. Methods: Forty-six patients were divided into four groups: periodontitis active site group, non-active site group, gingivitis group, and healthy group. IL-17, RORC2, IFN-γ, and IL-4 in GCF were detected by enzyme-linked immunosorbent assay (ELISA). Results: The expression trend of IL-17 and RORC2 were similar. The levels of IL-17 and RORC2 in active site group were significantly higher than those of other three groups, and the levels of non-active site group were significantly higher than that of healthy group (P<0.05). The expression of IFN-γ in healthy group was significantly lower than those of other three groups (P<0.05). In active periodontal site group, the expression level of IL-4 was significantly lower than those of other three groups (P<0.05). IL-17 level was positively correlated with RORC2, and negatively correlated with IL-4 (P<0.05). The levels of IL-17, RORC2 and IFN-γ were positively correlated with those of BI, PD and AL. The level of IL-4 was negatively correlated with those of BI, PD and AL (P<0.05). Conclusion: The expression of Th17 was strong in active site group, and it increased with the aggravation of attachment loss. IFN-γ might be involved in the transformation of gingival inflammation and non-inflammation status.

Key words: Periodontitis, IL-17, RORC2, IFN-γ, IL-4, GCF

CLC Number:

R781.4

YANG Dong, LI Hong-mei, LIU Lin-hua, DONG Wei-li. Detection of Th17 and Related Factors in Gingival Crevicular Fluid of Patients with Different Periodontal Inflammatory Status[J]. Journal of Oral Science Research, 2017, 33(11): 1161-1164.

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