Expression and Clinical Significance of CASZ1 in Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2022.01.007

Abstract

Abstract: Objective: To investigate the expression and clinical significance of CASZ1 in oral squamous cell carcinoma (OSCC). Methods: The expression of CASZ1 mRNA in OSCC was discussed through TCGA database. Immunohistochemical method was used to detect the expression of CASZ1 protein in OSCC and adjacent normal tissues, and to analyze the relationship between the expression of CASZ1 protein and the clinicopathological features and prognosis of OSCC patients. Results: The results of TCGA database showed that the expression level of CASZ1 mRNA was down regulated in OSCC (P<0.001). The low expression rate of CASZ1 protein in OSCC tissues (65.6%, 80/122) was significantly higher than that in normal tissues adjacent to cancer (34.9%, 22/63, P<0.001). The low expression of CASZ1 protein was related to the T stage (P<0.05). Kaplan-Meier analysis showed that the overall survival rate of patients in the low expression group of CASZ1 protein was significantly lower than that in the high expression group (P<0.05). The results of multivariate COX regression model analysis showed that the low expression of CASZ1 protein and the T stage were independent factors affecting the prognosis of patients (P<0.05). Conclusion: The expression level of CASZ1 in OSCC is significantly reduced, and the low expression of CASZ1 protein is related to the short survival time of OSCC patients, which may be a new potential marker for poor prognosis in OSCC patients.

Key words: prognosis, oral squamous carcinoma, transcription factor, CASZ1

QI Yuanli, YAN Hongjuan, Zumu reti-guli·ABLANTI, ZHANG Chaojie, ZHAO Juhong, XU Jiang. Expression and Clinical Significance of CASZ1 in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2022, 38(1): 30-33.

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