Research Progress of Saliva Extracellular Vesicles as Biological Markers in Diagnosis of Oral Diseases

doi:10.13701/j.cnki.kqyxyj.2021.05.002

Abstract

Abstract: Saliva is similar to blood and contains a large amount of biological information, which is the ideal body fluid for non-invasive diagnosis. Extracellular vesicles (EVs) are a group of cell-derived nanoscale heterogeneous vesicles existing in most body fluids (including saliva), mainly including exosomes and microvesicles. Extracellular vesicles are the common medium of inter-cell signal transmission between eukaryotic cells and prokaryotic cells, which can transmit signals to receptor cells, thus mediating inter-cell communication and signal transmission. At the same time, it plays an important role in various biological functions, including the transfer of biological active molecules such as proteins, nucleic acids and lipids, and the regulation of physiological and pathological processes of various diseases. Due to these characteristics, extracellular vesicles are considered to be valuable biological markers for diagnosis and prediction of various diseases. This article reviews the research progress of saliva extracellular vesicles as biological markers in the diagnosis of oral diseases

Key words: saliva, extracellular vesicles, biological markers, oral diseases, diagnosis

LUO Qinliang, HUANG Guilin. Research Progress of Saliva Extracellular Vesicles as Biological Markers in Diagnosis of Oral Diseases[J]. Journal of Oral Science Research, 2021, 37(5): 386-388.

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