Research Progress of NLRP3 Inflammasome in Peri-implantitis

doi:10.13701/j.cnki.kqyxyj.2022.12.004

Abstract

Abstract: NLRP3 inflammasome is a formation of a cytosolic multiprotein complex, which is involved in innate immune response. NLRP3 can activate proinflammatory cytokines such as interleukin-1β and interleukin-18 and then mediate pyroptosis. It plays an important role in maintaining immune balance and regulating the progression of inflammation. The occurrence of peri-implantitis is mainly due to the imbalance and destruction of the immune microenvironment around the peri-implant caused by oral biofilms and occlusal overload. Bacteria and their virulence factors, titanium particles, and occlusal overload can cause the activation of NLRP3 and eventually destroy periodontal tissues around the peri-implant. This review focuses on the production of NLRP3 in peri-implantitis and its mechanism of causing diseases.

Key words: NLRP3 inflammasome, peri-implantitis, interleukin

LI Birong, MENG Weiyan. Research Progress of NLRP3 Inflammasome in Peri-implantitis[J]. Journal of Oral Science Research, 2022, 38(12): 1119-1123.

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