Abstract: Objective: To optimize alveolar decortications-facilitated orthodontic and to study the mechanism underlying . Methods: In this study, 40 rabbits were randomly divided into 5 groups of 8 rabbits each. The left side of the mandible served as the experimental side, which was treated by alveolar decortication-facilitated orthodontic and the right side served as the control side. 4 oz force was applied to the mandibular first molar. The measurements on 8 rabbits were done on days 1, 3, 5, 7 and 14. Three of the animals at each time point were used for histological observation. The other five animals were used for molecular studies. Results: Histological observation demonstrated a higher count of osteoclasts and bone remodeling activity and two consecutive obvious growth in the experimental group. In addition, different cytokines of the osteoclast had different expression trend at the same time: the mRNA expression of CTSK and TRAP was markedly upregulated and reached its highest on the 5th day; the CTR mRNA was expressed evenly on day 1 through day 7, and the trend of JDP2 and NFATC1 expression was consistent, reaching its highest on the 7th day; the Fra2 expression increased on the 5th day and was significantly higher on days 5, 7, and 14 days. Conclusion: It suggests that among this procedure osteoclast may differentiate twice to accelerate roots movement.

Key words: Tooth movement, Accelerate osteogenic orthodontic , Bove remodeling , Cytokines , Osteo clasts