Expression and Clinical Significance of IGF-1R and IGFBP-3 in Oral Squamous Cell Carcinoma

Abstract

Abstract: Objective: To detect the expression of IGF-1R and IGFBP-3 in oral squamous cell carcinoma (OSCC), and explore its clinical and pathological significance. Methods: The expression levels of IGF-1R and IGFBP-3 in 66 cases of OSCC, 20 cases of adjacent tissues of OSCC and 50 cases of normal oral mucosa tissues were detected by immunohistochemistry of S-P staining. The data was statistically analyzed by SPSS19.0. Results: The expression of IGF-1R and IGFBP-3 in OSCC group, adjacent tissue of OSCC and normal group was successively decreased and significantly different (P＜0.05). The expression of IGF-1R and IGFBP-3 was negatively correlated in OSCC tissues (P<0.05). Conclusion: There were significant correlations between the expression of IGF-1R, IGFBP-3 and clinical and pathological features of OSCC.

Key words: Oral squamous cell carcinoma, IGF-1R, IGFBP-3, Immunohistochemistry

CLC Number:

R739.8

JIN Cheng-xue, LI Ming-he, YUE Li-wei, ZHANG Ru-hui. Expression and Clinical Significance of IGF-1R and IGFBP-3 in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2015, 31(10): 1000-1003.

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