Abstract: Objective: To investigate effects of periodental non-surgical treatment on serum IL-6 and alveolar bone absorption in rats with periodontitis and hyperlipidemia. Methods: The SD rats were separated into 4 groups:control group (A),HL group (B),CP group (C),and HL+CP group (D). After model establishment, group C and group D were randomly divided into group C1/D1 (natural process group) and group C2/D2 (scaling and root planning) according to random number table and received the corresponding oral intervention treatment respectively. Serum IL-6 levels were determined by enzyme linked immunosorbent assay (ELISA) respectively one week before the intervention, one week after the first intervention, one, three, five weeks after the second intervention. The unilateral maxilla was collected and stained by methylene blue, and the distance between CEJ and ABC (cementoenamel junction and alveolar bone crest) was measured. Results: Serum IL-6 of group C and D was obviously higher than that of group A (P<0.05). C1/D1 group showed an increased trend with time. The serum IL-6 of C2/D2 group was peaked one week after the second intervention, then gradually decreased and was lower than the baseline (P<0.05). The degree of alveolar bone loss was as follow: C, D group > A group (P<0.001). Serum level of IL-6 and alveolar bone resorption were positively correlated (P<0.01). Conclusion: Hyperlipidemia can aggravate the periodontitis degree, and periodontal basic treatment exacerbates the body's inflammatory response in the short term. To some extent, periodontal basic treatment can decrease the alveolar bone loss in periodontitis rats with or without hyperlipidemia.

Key words: Chronic periodontitis, Hyperlipidemia, Periodontal basic therapy, Interleukin 6, Alveolar bone absorption