Expression and Clinical Significance of Hippo Signaling Pathway Related Proteins YAP, MST1 and LATS1/2 in Oral Squamous Cell Carcinoma.

doi:10.13701/j.cnki.kqyxyj.2017.04.013

Abstract

Abstract: Objective: To research the expression of YAP, MST1 and LATS1/2 in oral squamous cell carcinoma and their correlation with the clinical data of the patients. Methods: Fifty-one cases of oral squamous cell carcinoma were collected from Xinjiang Medical University, and the survivals of the patients were followed up by telephone. Immunohistochemical staining was used to detect the expression of YAP, MST1 and LATS1/2 in oral squamous cell carcinoma tissues and the clinical data were statistically analyzed. Results: The expression of YAP, LATS1/2 and MST1 were related to the tumor size and degree of differentiation (P<0.05). YAP and LATS1/2 were related with lymph node metastasis (P<0.05), and MST1 was not related with lymph node metastasis. YAP, LATS1/2 and MST1 were not related with gender and age, family name, and the metastasis of the tumor. Conclusion: Hippo signaling pathway related proteins have a certain effect on tumor size, differentiation degree and lymph node metastasis.

Key words: Hippo pathway , YAP, Oral squamous cell carcinoma

CLC Number:

R739.8

WANG Xue-yang, ZHOU Yu-chuan, CHEN Qing-li, GONG Zhong-cheng, LIN Zhao-quan. Expression and Clinical Significance of Hippo Signaling Pathway Related Proteins YAP, MST1 and LATS1/2 in Oral Squamous Cell Carcinoma.[J]. Journal of Oral Science Research, 2017, 33(4): 400-403.

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