口腔医学研究

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (3): 243-246.DOI: 10.13701/j.cnki.kqyxyj.2020.03.013

• 修复材料抗菌性研究 • 上一篇    下一篇

纳米无机载银磷酸锆树脂基托对6种口腔细菌的体外抗菌研究

杨成雪, 翟羽翔, 王开梅, 陈林*   

  1. 遵义医科大学附属口腔医院 贵州 遵义 563003
  • 收稿日期:2019-06-20 出版日期:2020-05-15 发布日期:2020-05-15
  • 通讯作者: 陈林,E-mail:1361024499@qq.com
  • 作者简介:杨成雪(1987~),男,贵州遵义人,硕士,主治医师,主要从事义齿微生态学与义齿基托材料研究。
  • 基金资助:
    贵州省科技技术厅联合基金项目(Ck-836)号;贵州省遵义市红花岗科技局项目2019(26)号;遵义医学院硕士启动基金KY2017-05号

Antimicrobial Activity of Resin Base with Nano-silver Inorganic Zirconium Phosphate against Six Oral Bacteria in Vitro

YANG Chengxue, ZHAI Yuxiang, WANG Kaimei, CHEN Lin*   

  1. Stomatological Hospital Affiliated to Zunyi Medical College, Zunyi 563000, China
  • Received:2019-06-20 Online:2020-05-15 Published:2020-05-15

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摘要： 目的：通过体外粘附实验,研究纳米无机载银磷酸锆加入到树脂基托中后是否具有抗菌性。方法：将纳米无机载银磷酸锆(Conval PAg-40型)按1%、3%、5%、7%比例添加到树脂基托中制成树脂片,未添加者为对照组,打磨抛光,金相显微镜观察试件表面无划痕、粗糙度测定仪测得表面粗糙度值无统计学差异后,采用薄膜密贴法检测该抗菌树脂片对变形链球菌、黏性放线菌、内氏放线菌、血链球菌、牙龈卟啉单胞菌、白色念珠菌的抗菌性,比较分析树脂基托抗菌性能与添加抗菌剂比例的相关性。结果：3%、5%、7%组培养的牙龈卟啉单胞菌以及1%、3%、5%、7%组培养的变形链球菌、黏性放线菌、内氏放线菌、血链球菌、白色念珠菌菌落数均低于对照组,差异有统计学意义(P＜0.05),抗菌率随添加比例的增加逐渐升高;1%组培养的牙龈卟啉单胞菌菌落数与对照组相比差异无统计学意义(P＞0.05)。结论：纳米无机载银磷酸锆树脂基托有良好的抗菌效能,其抗菌率随抗菌剂比例的添加而呈线性上升趋势。

关键词: 义齿树脂基托, 纳米无机载银磷酸锆, 抗菌

Abstract: Objective: To study whether the nano-silver inorganic zirconium phosphate has antibacterial properties after being added to resin base by adhesion experiments in vitro. Methods: The nano-silver inorganic zirconium phosphate (Conval PAg-40) was added to the resin base at the ratio of 1%, 3%, 5%, and 7% to prepare resin specimens. The antimicrobial properties of all resin specimens against Streptococcus mutans, Actinomyces viscosus, Actinomyces naeslundii, Streptococcus sanguis, Porphynomoans gingivalis, and Candida albicans were tested by the film-sticking method after those specimens were milled and polished. The surface roughness values were measured by the roughness tester. Results: The colonies of Porphyromonas gingivalis cultured in groups of 3%, 5%, and 7%, and Streptococcus mutans, Actinomyces viscosus, Actinomyces naeslundii, Streptococcus sanguis, and Candida albicans cultured in groups of 1%, 3%, 5%, and 7% were lower than the control group (P<0.05). The antimicrobial rate of resin specimens gradually increased with the increase of addition. There was no significant difference in the number of Porphyromonas gingivalis colonies cultured in 1% group compared with that of the control group (P>0.05). Conclusion: The resin base with nano-silver inorganic zirconium phosphate has good antimicrobial activity, and its antimicrobial rate increases linearly with the proportion of antimicrobial agents.

Key words: denture resin base, nano-silver inorganic zirconium phosphate, antibacterial