Correlation of Signal Pathway in Periodontitis and Atherosclerosis.

doi:10.13701/j.cnki.kqyxyj.2018.12.002

Abstract

Abstract: The incidence of chronic periodontitis (CP) is over 70% in the over 65 years old people in China.And the prevalence of atherosclerosis (AS) is increasing with the change of dietary structure.A large number of studies reported that there are common risk factors between CP and AS.CP, a chronic multi-factor inflammatory disease caused by microorganisms, is closely related to AS which is based on chronic infection and is a key basic pathological of cardiovascular disease.Porphyromonas gingivalis (P.g.) is a main periodontal pathogen to CP.From gingival epithelium, P.g.enters the bloodstream, which causes the endothelial dysfunction, releases the inflammatory cytokines, turns macrophages phagocytose lipids into foam cells, and causes the formation of atheroslerotic plaque.This article discussed the association between CP and AS.

Key words: Atherosclerosis, Periodontitis, Porphyromonas gingivalis

HUANG Lin-yan, LAI Ren-fa, HUANG Yi. Correlation of Signal Pathway in Periodontitis and Atherosclerosis.[J]. Journal of Oral Science Research, 2018, 34(12): 1271-1273.

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