Advances of Macrophage Colony-stimulating Factor-1 and Its Receptor in Periodontitis

doi:10.13701/j.cnki.kqyxyj.2024.03.003

Abstract

Abstract: Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth. The host immune response is now recognized as the primary cause of tissue damage in periodontitis. Current clinical treatment mainly focuses on removing plaque and calculus mechanically, with limited use of immunotherapy. Nevertheless, it is essential to research immunotherapy for periodontitis. Macrophages play a pivotal role in the host immune response. They recognize, phagocytose, and eliminate foreign pathogens and objects. The colony stimulation factor-1 (CSF-1)/colony stimulation factor-1 receptor (CSF-1R) pathway is involved in the progression of periodontitis by regulating macrophage inflammation and osteoclast bone resorption. Understanding the mechanism of action of CSF-1/CSF-1R in periodontitis is essential for future studies and the development of immunotherapy approaches.

Key words: macrophage colony stimulation factor-1, macrophage colony stimulation factor-1 receptor, macrophage, osteoclast, periodontitis

ZHAN Jifan, TIAN Ai. Advances of Macrophage Colony-stimulating Factor-1 and Its Receptor in Periodontitis[J]. Journal of Oral Science Research, 2024, 40(3): 199-205.

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