Research Progress on Roles of Osteoclasts in Chronic Apical Periodontitis

doi:10.13701/j.cnki.kqyxyj.2025.05.001

Abstract

Abstract: Chronic apical periodontitis is frequently characterized by alveolar bone resorption, with osteoclast differentiation and proliferation playing pivotal roles in its development. Research indicates that various factors and enzymes associated with chronic apical periodontitis can either promote or inhibit osteoclast function which influenced the response of osteocytes in the affected areas. Moreover, scholarly attention is increasingly focusing on the treatment of chronic apical periodontitis. Strategies targeting relevant pathways, such as inhibiting NF-κB activation or activating the PI3K signaling pathway, are considered promising. Nevertheless, these therapeutic interventions require further clinical investigation, and their efficacy in clinical settings warrants evaluation. This article aims to provide a comprehensive review of current advancements concerning the role of osteoclasts and potential treatment modalities for chronic apical periodontitis.

Key words: chronic apical periodontitis, oral disease, osteoclasts, bone resorption

WEI Xiaoxuan, LI Bolei. Research Progress on Roles of Osteoclasts in Chronic Apical Periodontitis[J]. Journal of Oral Science Research, 2025, 41(5): 363-368.

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