Research Progress of Platelet Concentrates in Promoting Peripheral Nerve Regeneration

doi:10.13701/j.cnki.kqyxyj.2020.06.002

Abstract

Abstract: Peripheral nerve injury is a common disease in stomatology, which can cause varying degrees of sensory and motor dysfunctions. In addition, osseoperception plays an important role in the long-term stability of implants. Platelet concentrates contain a large number of growth factors, which can promote and induce the regeneration and repair of peripheral nerves. Therefore, using platelet concentrates to promote the recovery of injured nerves and the regeneration of implant peripheral nerves have become an important research direction. This article reviews the mechanism of peripheral nerve regeneration, the classification of platelet concentrates, and their regeneration effects on peripheral nerve.

Key words: peripheral nerve regeneration, platelet concentrates, platelet-rich plasma, platelet-rich fibrin, concentrated growth factor

LIU Chunying, ZHOU Yanmin. Research Progress of Platelet Concentrates in Promoting Peripheral Nerve Regeneration[J]. Journal of Oral Science Research, 2020, 36(6): 509-511.

References

[1] Bhatnagar VM, Karani JT, Khanna A, et al. Osseoperception: an implant mediated sensory motor control-a review[J]. J Clin Diagn Res, 2015, 9(9):ZE18-ZE20.
[2] Sánchez M, Garate A, Delgado D, et al. Platelet-rich plasma, an adjuvant biological therapy to assist peripheral nerve repair[J]. Neural Regen Res, 2017, 12(1):47-52.
[3] Allodi I, Udina E, Navarro X. Specificity of peripheral nerve regeneration:interactions at the axon level[J]. Prog Neurobiol, 2012, 98(1): 16-37.
[4] Masuki H, Okudera T, Watanebe T, et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors(CGF)[J]. Int J Implant Dent, 2016, 2(1): 19.
[5] Rosner BI, Hang T, Tranquillo RT. Schwann cell behavior in three-dimensional collagen gels: evidence for differential mechano-transduction and the influence of TGF-beta 1 in morphological polarization and differentiation[J]. Exp Neurol, 2005, 195(1):81-91.
[6] Funa K, Sasahara M. The roles of PDGF in development and during neurogenesis in the normal and diseased nervous system[J]. J Neuroimmune Pharmacol, 2014, 9(2): 168-181.
[7] Ikeda M, Uemura T, Takamatsu K, et al. Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system[J]. J Biomed Mater Res A, 2014, 102:1370-1378.
[8] Zheng C, Zhu Q, Liu X, et al. Effect of platelet-rich plasma (PRP) concentration on proliferation, neurotrophic function and migration of Schwann cells in vitro[J]. J Tissue Eng Regen Med, 2016, 10(5): 428-436.
[9] Qin J, Wang L, Sun Y, et al. Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo[J]. Int J Mol Med, 2016, 37(2): 493-500.
[10] 吴晶洋,白艳洁,王稚英.富血小板纤维蛋白和浓缩生长因子对施万细胞影响的比较[J].中国医科大学学报,2016,45(12):1089-1093.
[11] Rao SN, Pearse DD. Regulating axonal responses to injury: the intersection between signaling pathways involved in axon myelination and the inhibition of axon regeneration[J]. Front Mol Neurosci, 2016, 9:33.
[12] Moussa M, Lajeunesse D, Hilal G, et al. Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage[J]. Exp Cell Res, 2017, 352(1):146-156.
[13] Teymur H, Tiftikcioglu YO, Cavusoglu T, et al. Effect of platelet-rich plasma on reconstruction with nerve autografts[J].Kaohsiung J Med Sci, 2017, 33(2):69-77.
[14] Matsumine H, Sasaki R, Tabata Y, et al. Facial nerve regeneration using basic fibroblast growth factor-impregnated gelatin microspheres in a rat model[J]. J Tissue Eng Regen Med, 2016, 10(10): 559-567.
[15] Takeuchi M, Kamei N, Shinomiya R, et al. Human platelet-rich plasma promotes axon growth in brain-spinal cord coculture[J]. Neuroreport, 2012, 23:712-716.
[16] Kim JY, Jeon WJ, Kim DH, et al. An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats[J]. Neural Regen Res, 2014, 9:1351-1357.
[17] 刘旸.富血小板纤维蛋白促进面神经挤压伤修复的实验研究[D].遵义医学院,2018.
[18] Anitua E, Pascual C, Antequera D, et al. Plasma rich in growth factors (PRGF-Endoret) reduces neuropathologic hallmarks and improves cognitive functions in an Alzheimer’s disease mouse model[J]. Neurobiol Aging, 2014, 35(7): 1582-1595.
[19] Park GY, Kwon DR. Platelet-rich plasma limits the nerve injury caused by 10% dextrose in the rabbit median nerve[J]. Muscle Nerve, 2014, 49(1): 56-60.
[20] Kakudo N, Morimoto N, Kushida S, et al. Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo[J]. Med Mol Morphol, 2014, 47(2):83-89.
[21] Ikumi A, Hara Y, Okano E, et al. Intraoperative local administration of platelet-rich plasma (PRP) during neurolysis surgery for the treatment of digital nerve crush injury[J/OL]. Case Rep Orthop, 2018, 2018:1275713.
[22] García de Cortázar U, Padilla S, Lobato E, et al. Intraneural platelet-rich plasma injections for the treatment of radial nerve section: a case report[J]. J Clin Med, 2018, 7(2):13.
[23] 付丽,孙悦,翟婧捷,等.3D打印及CGF在双侧下牙槽神经移位同期牙种植术中的应用[J]. 口腔医学研究, 2016, 32(10):1003-1005.
[24] Piskin A, Kaplan S, Aktaş A, et al. Platelet gel does not improve peripheral nerve regeneration: an electrophysiological, stereological, and electron microscopic study[J].Microsurgery, 2009, 29(2):144-153.
[25] Bayram B, Akdeniz SS, Diker N, et al. Effects of platelet-rich fibrin membrane on sciatic nerve regeneration[J]. J Craniofac Surg, 2018, 29(3):239-243.
[26] Şenses F, Önder ME, Koçyiğit ID, et al. Effect of platelet-rich fibrin on peripheral nerve regeneration[J]. J Craniofac Surg, 2016, 27(7): 1759-1764.