Anti-biofilm Effect of Sustained Release Limonin Polymer Nanopolymer

doi:10.13701/j.cnki.kqyxyj.2021.05.007

Abstract

Abstract: Objective: To study the anti-biofilm effect and sustained release properties of LIM/PLGA-PEG. Methods: Limonin loaded polymer nanoparticles were prepared and characterized. The anti-Streptococcus mutans and anti-biofilm properties were determined. LLIM/PLGA-PEG release curve (material toxicity) and cytotoxicity were measured. Results: LIM/PLGA-PEG showed anti Streptococcus mutans (MIC=1.56 mg/mL) property. Subinhibitory concentrations of these nanoparticles reduced the biofilm formation by 92%. The slow release of LIM/PLGA-PEG was detected in neutral and acidic environment within 12 hours. The IC50 of the nanoparticles was 15.63 μg/mL. Conclusion: The limonin nanoparticles have anti caries activity and sustained-release effect in acidic environment, which is expected to be used in the control of dental caries

Key words: nanoparticles, limonin, antibacterial, sustained release

XU Yanglong. Anti-biofilm Effect of Sustained Release Limonin Polymer Nanopolymer[J]. Journal of Oral Science Research, 2021, 37(5): 407-411.

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