Drugs Loaded Hierarchically Electrospraying Composite Microspheres Support Dental Alveolar Bone Augmentation

doi:10.13701/j.cnki.kqyxyj.2021.05.016

Abstract

Abstract: Objective: To construct PLGArhBMP2@CSPac525 composite microspheres by electrospraying and study their anti-bacteria and osteogenic effects in dental alveolar bone augmentation. Methods: PLGArhBMP2@CSPac525 composite microspheres were fabricated by hierarchically electrospraying. SEM, UV-Vis, and ELISA examination were performed to test the morphology and encapsulation efficiency of composite microspheres. Inhibitor ring test and alkaline phosphatase staining were used to verify the anti-bacteria and osteogenic bioactivity of Pac525 and rhBMP2 loaded in microspheres. Results: The composite microspheres demonstrated ideal sphere-in-sphere structure. The encapsulation efficiencies of Pac525 and rhBMP2 were both more than 90%. Diameter of inhibition ring was more than 10 mm with elution at 30th day, and significant alkaline phosphatase staining were found after osteogenic inducing with elusion for 7 days. Conclusion: These hierarchically microspheres might be serve as a promising, reliable and efficient multi-function bioactive scaffold for pre-implantation bone augmentation

Key words: hierarchically electrospraying, composite microsphere, anti-bacteria, osteogenic

YE Weilong, ZHENG Jingchuan, HUANG Jiaqian, ZHAO Pengcheng, LIU Zhu, MA Guowu. Drugs Loaded Hierarchically Electrospraying Composite Microspheres Support Dental Alveolar Bone Augmentation[J]. Journal of Oral Science Research, 2021, 37(5): 458-461.

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