Formation of Alendronate Sodium and Collagen Type I Complex Films on the Nano-hydroxyapatite Surface.

doi:10.11839/kqyxzh.2016.01.006

Abstract

Abstract: Objective: To form a stable and repeatable alendronate sodium (ALN) and collagen type I (COL I) complex films on nano-hydroxyapatite (nHA) layer. Methods: A nHA layer was coated on the pure titanium (PT) surface by using electrochemical deposition, then ALN and COL I were chemically bonded on the nHA layer to form nHA/ALN/COL I and nHA/COL I/ALN complex films using 3-aminopropyl triethoxysilane (APTES) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) as coupling agent. The nHA layer was characterized by scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray diffractometer (XRD), and the complex films were characterized by X-ray photoelectron spectrometer (XPS) and Fourier transform infrared spectroscopy (FTIR). Results: ALN and COL I were bonded on the nHA layer by coupling agent, nHA/ALN/COL I and nHA/COL I/ALN complex films were formed by changing the binding order of ALN and COL I. Conclusion: The nHA/ALN/COL I and nHA/COL I/ALN complex films formed by chemical covalent bonding method have different potentials of ALN sustained-release.

CLC Number:

R783.1

JIANG Yan, YAO Jiang-Wu.. Formation of Alendronate Sodium and Collagen Type I Complex Films on the Nano-hydroxyapatite Surface.[J]. Journal of Oral Science Research, 2016, 32(1): 21-25.

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