Research Progress of Microporous Bioceramic Scaffolds in Bone Tissue Engineering

doi:10.13701/j.cnki.kqyxyj.2022.01.004

Abstract

Abstract: Bone tissue engineering has been focused on the design of optimal scaffold structure to promote bone regeneration. Recently, many studies have shown that the microporous structure plays an important role in the osteogenesis of bioceramic scaffolds. This article summarizes the research progress of microporous bioceramic scaffolds in bone tissue engineering from three aspects: mechanical properties, osteogenesis mechanism, and application as a carrier in bone repair.

Key words: micropore, bioceramic, bone tissue engineering, bone regeneration

CHEN Yi, WU Yanmin. Research Progress of Microporous Bioceramic Scaffolds in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2022, 38(1): 17-19.

References

[1] Turnbull G, Clarke J, Picard F, et al. 3D bioactive composite scaffolds for bone tissue engineering [J]. Bioact Mater, 2018, 3(3):278-314.
[2] Abbasi N, Hamlet S, Love RM, et al. Porous scaffolds for bone regeneration [J]. J Sci-Adv Mater Dev,2020,5(1):1-9.
[3] Perez RA, Mestres G. Role of pore size and morphology in musculo-skeletal tissue regeneration [J]. Mater Sci Eng C Mater Biol Appl, 2016, 61:922-939.
[4] Rustom LE, Poellmann MJ, Wagoner Johnson AJ. Mineralization in micropores of calcium phosphate scaffolds [J]. Acta Biomater, 2019, 83:435-455.
[5] Ribas RG, Schatkoski VM, Montanheiro TLdA, et al. Current advances in bone tissue engineering concerning ceramic and bioglass scaffolds: A review [J]. Ceram Int, 2019, 45(17):21051-21061.
[6] Shen J, Yang X, Wu R, et al. Direct ink writing core-shell Wollastonite@Diopside scaffolds with tailorable shell micropores favorable for optimizing physicochemical and biodegradation properties [J]. J Eur Ceram Soc, 2020, 40(2):503-512.
[7] Dellinger JG, Wojtowicz AM, Jamison RD. Effects of degradation and porosity on the load bearing properties of model hydroxyapatite bone scaffolds [J]. J Biomed Mater Res A, 2006, 77(3):563-571.
[8] Lan Levengood SK, Polak SJ, Wheeler MB, et al. Multiscale osteointegration as a new paradigm for the design of calcium phosphate scaffolds for bone regeneration [J]. Biomaterials, 2010, 31(13):3552-3563.
[9] Bohner M, Baroud G, Bernstein A, et al. Characterization and distribution of mechanically competent mineralized tissue in micropores of β-tricalcium phosphate bone substitutes [J]. Mater Today, 2017, 20:106-115.
[10] Zhang J, Luo X, Barbieri D, et al. The size of surface microstructures as an osteogenic factor in calcium phosphate ceramics [J]. Acta Biomater, 2014, 10(7):3254-3263.
[11] Wei J, Jia J, Wu F, et al. Hierarchically microporous/macroporous scaffold of magnesium-calcium phosphate for bone tissue regeneration [J]. Biomaterials, 2010, 31(6):1260-1269.
[12] Habibovic P, Yuan H, van der Valk CM, et al. 3D microenvironment as essential element for osteoinduction by biomaterials [J]. Biomaterials, 2005, 26(17):3565-3575.
[13] Polak SJ, Lee JS, Murphy WL, et al. Microstructural control of modular peptide release from microporous biphasic calcium phosphate [J]. Mater Sci Eng C Mater Biol Appl, 2017, 72:268-277.
[14] 傅文麒,刘慧颖.种植体表面生物活性元素的添加及其对骨免疫微环境的调控[J].口腔医学研究,2020,36(10):908-911.
[15] Tang Z, Li X, Tan Y, et al. The material and biological characteristics of osteoinductive calcium phosphate ceramics [J]. Regen Biomater, 2018, 5(1):43-59.
[16] Tang H, Guo Y, Jia D, et al. High bone-like apatite-forming ability of mesoporous titania films [J]. Microporous Mesoporous Mater, 2010, 131(1-3):366-372.
[17] Xin T, Mao J, Liu L, et al. Programmed sustained release of recombinant human bone morphogenetic protein-2 and inorganic ion composite hydrogel as artificial periosteum [J]. ACS Appl Mater Interfaces, 2020, 12(6):6840-6851.
[18] Polak SJ, Rustom LE, Genin GM, et al. A mechanism for effective cell-seeding in rigid, microporous substrates [J]. Acta Biomater, 2013, 9(8):7977-7986.
[19] Rustom LE, Boudou T, Lou S, et al. Micropore-induced capillarity enhances bone distribution in vivo in biphasic calcium phosphate scaffolds [J]. Acta Biomater, 2016, 44:144-154.
[20] Oh DS, Kim YJ, Hong MH, et al. Effect of capillary action on bone regeneration in micro-channeled ceramic scaffolds [J]. Ceram Int, 2014, 40(7):9583-9589.
[21] Xiao D, Zhang J, Zhang C, et al. The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved [J]. Acta Biomater, 2020, 106:22-33.
[22] Zhang J, Barbieri D, Ten Hoopen H, et al. Microporous calcium phosphate ceramics driving osteogenesis through surface architecture [J]. J Biomed Mater Res A, 2015, 103(3):1188-1199.
[23] Almas K, Smith S, Kutkut A. What is the best micro and macro dental implant topography? [J]. Dent Clin North Am, 2019, 63(3):447-460.
[24] Lei L, Han J, Wen J, et al. Biphasic ceramic biomaterials with tunable spatiotemporal evolution for highly efficient alveolar bone repair [J]. J Mater Chem B, 2020,8(35):8037-8049.
[25] Dang HP, Shabab T, Shafiee A, et al. 3D printed dual macro-, microscale porous network as a tissue engineering scaffold with drug delivering function [J]. Biofabrication, 2019, 11(3):035014.
[26] Parent M, Magnaudeix A, Delebassée S, et al. Hydroxyapatite microporous bioceramics as vancomycin reservoir: Antibacterial efficiency and biocompatibility investigation [J]. J Biomater Appl, 2016, 31(4):488-498.
[27] Chai F, Hornez JC, Blanchemain N, et al. Antibacterial activation of hydroxyapatite (HA) with controlled porosity by different antibiotics [J]. Biomol Eng, 2007, 24(5):510-514.
[28] Zhang J, Zhou H, Yang K, et al. RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration [J]. Biomaterials, 2013, 34(37):9381-9392.
[29] Kakuta A, Tanaka T, Chazono M, et al. Effects of micro-porosity and local BMP-2 administration on bioresorption of β-TCP and new bone formation [J]. Biomater Res, 2019, 23(1):12.