Advance in Endodontic Regeneration Treatment of Immature Permanent Teeth

doi:10.13701/j.cnki.kqyxyj.2022.05.005

Abstract

Abstract: Endodontic regeneration treatment refers the best use of biological and tissue engineering techniques that protect dental pulp cells, dental papilla mesenchymal stem cells, and periodontal ligament stem cells by perfecting and effective root canal disinfection. Blood clots provides a good microenvironment for stem cell proliferation and differentiation and promotes the continued root development. This article introduces the historical research, biological basis, indications, procedures, efficacy evaluation, and complications of pulp revascularization of immature permanent teeth and provides guidance for clinical operations.

Key words: immature permanent teeth, pulp revascularization, stem cells

Reziyaguli·AKEMU, YANG Guobin. Advance in Endodontic Regeneration Treatment of Immature Permanent Teeth[J]. Journal of Oral Science Research, 2022, 38(5): 408-411.

References

[1] Liu WZ, Su LY, Xie XD, et al. Prevalence and years lived with disability for dental caries among children aged 0-14 years in China, 1990-2016 [J]. Biomed Environ Sci, 2018, 31(5): 376-381.
[2] Hecova H, Tzigkounakis V, Merglova V, et al. A retrospective study of 889 injured permanent teeth [J]. Dent Traumatol, 2010, 26(6): 466-475.
[3] Kahler B, Rossi-Fedele G, Chugal N, et al. An evidence-based review of the efficacy of treatment approaches for immature permanent teeth with pulp necrosis [J]. J Endod, 2017, 43(7): 1052-1057.
[4] Nygaard-Ostby B, Hjortdal O. Tissue formation in the root canal following pulp removal [J]. Scand J Dent Res, 1971, 79(5): 333-349.
[5] Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract [J]. Dent Traumatol, 2001, 17(4): 185-187.
[6] Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: New treatment protocol? [J]. J Endod, 2004, 30(4): 196-200.
[7] Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action [J]. J Endod, 2007, 33(4): 377-390.
[8] Huang GT, Lin LM. Letter to the editor: comments on the use of the term "revascularization" to describe root regeneration [J]. J Endod, 2008, 34(5): 511.
[9] American Dental Association. CDT 2011-2012:the ADA practical guide to dental procedure codes [C]. Chicago. 2010.
[10] American Association of Endodontists (AAE). Clinical Considerations for a Regenerative Procedure. Revised 2016 [EB/OL]. Https://www.aae.org/uploadedfiles/publications and research/ research/ current regenerative endodontic considerations.pdf.
[11] European Society of Endodontology (ESE). European Society of Endodontology position statement: revitalization procedures [J]. Int Endod J, 2016, 49(8): 717-723.
[12] Dhillon H, Kaushik M, Sharma R, et al. Regenerative endodontics-creating new horizons [J]. J Biomed Mater Res B Appl Biomater, 2016, 104(4): 676-685.
[13] Xuan K, Li B, Guo H, et al. Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth [J]. Sci Transl Med, 2018, 10(455): eaaf3227.
[14] Kunimatsu R, Nakajima K, Awada T, et al. Comparative characterization of stem cells from human exfoliated deciduous teeth, dental pulp, and bone marrow-derived mesenchymal stem cells [J]. Biochem Biophys Res Commun, 2018, 501(1):193-198.
[15] Tsutsui TW. Dental pulp stem cells: advances to applications [J]. Stem Cells Cloning, 2020, 13: 33-42.
[16] Gupte MJ, Ma PX. Nanofibrous scaffolds for dental and craniofacial applications [J]. J Dent Res, 2012, 91(3): 227-234.
[17] Cymerman JJ, Nosrat A. Regenerative endodontic treatment as a biologically based approach for non-surgical retreatment of immature teeth [J]. J Endod, 2020, 46(1):44-50.
[18] Kim SG, Malek M, Sigurdsson A, et al. Regenerative endodontics: a comprehensive review [J]. Int Endod J, 2018, 51(12): 1367-1388.
[19] Kim SG. Biological molecules for the regeneration of the pulp-dentin complex [J]. Dent Clin North Am, 2017, 61(1): 127-141.
[20] Horsophonphong S, Sercia A, França CM, et al. Equivalence of human and bovine dentin matrix molecules for dental pulp regeneration: proteomic analysis and biological function [J]. Arch Oral Biol, 2020, 119:104888.
[21] Estefan BS, Batouty KM, Nagy MM, et al. In fluence of age and apical diameter on the success of endodontic regeneration procedures [J]. J Endod, 2016, 42(11): 1620-1625.
[22] 黄定明,杨懋彬,周学东.牙髓再生治疗的临床操作管理及疗效评价[J].中华口腔医学杂志,2019,54(9): 584-590.
[23] Koç S, Del Fabbro M. Does the etiology of pulp necrosis affect regenerative endodontic treatment outcomes? A systematic review and meta-analyses [J]. J Evid Based Dent Pract, 2020, 20(1): 101400.
[24] Cvek M. Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha. A retrospective clinical study [J]. Endod Dent Traumatol ,1992, 8(2): 45-55.
[25] Fang Y, Wang X, Zhu J, et al. Influence of apical diameter on the outcome of regenerative endodontic treatment in teeth with pulp necrosis: a review [J]. J Endod, 2018, 44(3): 414-431.
[26] Dioguardi M, Gioia GD, Illuzzi G, et al. Endodontic irrigants: different methods to improve efficacy and related problems [J]. Eur J Dent, 2018, 12(3): 459-466.
[27] Martin DE, De Almeida JF, Henry MA, et al. Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation [J]. J Endod, 2014, 40(1): 51-55.
[28] Galler KM, Buchalla W, Hiller KA, et al. Influence of root canal disinfectants on growth factor release from dentin [J]. J Endod, 2015, 41(3): 363-368.
[29] Galler KM, Widbiller M, Buchalla W, et al. EDTA conditioning of dentine promotes adhesion, migration and differentiation of dental pulp stem cells [J]. Int Endod J, 2016, 49(6): 581-590.
[30] Sathorn C, Parashos P, Messer M. Antibacterial efficacy of calcium hydroxide intracanal dressing: a systematic review and meta-analysis [J]. Int Endod J, 2007, 40(1): 2-10.
[31] Kitikuson P, Srisuwan T. Attachment ability of human apical papilla cells to root dentin surfaces treated with either 3Mix or calcium hydroxide [J]. J Endod, 2016, 42(1): 89-94.
[32] Kahler SL, Shetty S, Andreasen FM, et al. The effect of long-term dressing with calcium hydroxide on the fracture susceptibility of teeth [J]. J Endod, 2018, 44(3): 464-469.
[33] Ruparel NB, Teixeira FB, Ferraz CC, et al. Direct effect of intracanal medicaments on survival of stem cells of the apical papilla [J]. J Endod, 2012, 38(10): 1372-1375.
[34] Akman M, Akbulut MB, Aydinbelge HA, et al. Comparison of different irrigation activation regimens and conventional irrigation techniques for the removal of modified triple antibiotic paste from root canals [J]. J Endod, 2015, 41(5): 720-724.
[35] Kim TH, Kim SH, Sándor GK, et al. Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) in rabbit-skull defect healing [J]. Arch Oral Biol, 2014, 59(5): 550-558.
[36] Hong S, Chen W, Jiang B. A comparative evaluation of concentrated growth factor and platelet-rich fibrin on the proliferation, migration and differentiation of human stem cells of the apical papilla [J]. J Endod, 2018, 44(6): 977-983.
[37] Tong HJ, Rajan S, Bhuujel N, et al. Regenerative endodontic therapy in the management of nonvital immature permanent teeth: a systematic review-outcome evaluation and meta-analysis [J]. J Endod, 2017, 43(9): 1453-1464.
[38] Torabinejad M, Nosrat A, Verma P, et al. Regenerative endodontic treatment or mineral trioxide aggregate apical plug in teeth with necrotic pulps and open apices: a systematic review and meta-analysis [J]. J Endod, 2016, 43(11): 1806-1820.