Advancement in Epigenetics of Periodontal Ligament Stem Cells

doi:10.13701/j.cnki.kqyxyj.2021.11.005

Abstract

Abstract: Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells in periodontal ligament tissue, which are important cell group for periodontal tissue regeneration and repair. Changes of periodontal microenvironment will affect the biological characteristics of PDLSCs. Epigenetics has no changes in DNA sequence. It refers to changes in gene expression levels and functions. Environmental factors are one of the important influencing factors of epigenetics. Different environments exposure can cause changes in epigenetic modification, which in turn affect gene expression. Epigenetics is an important regulatory mechanism for the biological characteristics of stem cells. These changes in stem cells are stable, heritable, and reversible. In recent years, epigenetic regulation of PDLSCs has become a hot research topic. To make PDLSCs better applied to periodontal regeneration repair, this article reviews the effects of epigenetic regulation on the biological characteristics of periodontal ligament stem cells.

Key words: epigenetics, periodontal ligament stem cells, DNA methylation, histonemodification, non-coding RNA regulation

ZHANG Kun, LIU Yali. Advancement in Epigenetics of Periodontal Ligament Stem Cells[J]. Journal of Oral Science Research, 2021, 37(11): 976-980.

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