Research Progress of MicroRNA in Osteogenic Differentiation of Periodontal Ligament Stem Cells

doi:10.13701/j.cnki.kqyxyj.2022.03.004

Abstract

Abstract: Periodontitis is a common chronic infectious disease, which can lead to the progressive destruction of periodontal supporting tissues. Periodontal ligament stem cells have the ability of osteogenic differentiation, which have broad application prospects in the field of periodontal tissue regeneration. MicroRNA (miRNA) is a non-coding single stranded RNA with a length of 18-25 nucleotides. It can target the 3 'untranslated region (UTR) of mRNA, resulting in degradation of mRNA or inhibition of mRNA translation. In recent years, many scholars have studied the osteogenic regulation of miRNA, and a variety of miRNA have been confirmed to be involved in the osteogenic regulation of periodontal ligament stem cells. In this paper, the current research progress of miRNA in regulating the osteogenic differentiation of periodontal ligament is reviewed.

Key words: microRNA, periodontal ligament stem cells, osteogenic differentiation, exosome

ZHAO Jun, LIU Lina. Research Progress of MicroRNA in Osteogenic Differentiation of Periodontal Ligament Stem Cells[J]. Journal of Oral Science Research, 2022, 38(3): 220-222.

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