Empirical Study of Reparation of Periodontal Bone Defects Treated with PRP and Calcined Bone Composite.

Abstract

Abstract: Objective: To study the dissimilar calcined bone and Bio-oss bone respectively, and composite with platelet rich fibrin (platdet-rich fibrin, PRF), and their respective alone on the effect of periodontal bone defects. Methods: Calcined bone, PRF gel and complex were prepared. 54 rabbits were selected. Periodontal tissue defect model was randomly divided into control group, PRF gel group, calcined bone group, Bio-oss bone group, calcined bone/PRF group, Bio-oss bone/PRF group. After four weeks, eight weeks and l2 weeks the animals were sacrificed for a complete specimen, radiological and histological observation. Histological staining was used to measure the height of newborn periodontal tissues. Results: X-ray results showed that: 4 weeks, 8 weeks and l2 weeks calcined bone/PRF group and Bio-oss/PRF group were significantly higher than the average density, and bone tissue defects continuously. The experimental group was seen in root surfaces like tissue formation of new cementum , periodontal ligament and alveolar bone -like tissue matures over time, increasing. 12 weeks , the calcined bone/PRF, Bio-oss bone/PRF significantly improved compared with the control group, compared with the other three groups were statistically significant (P<0.05). Conclusion: Calcined bone/PRF gel and Bio-oss bone/PRF gel complexes can significantly promote the regeneration of periodontal tissues.

Key words: Platelet-rich fibrin , Calcined bone , Periodontal tissue regeneration

CLC Number:

R781.4

DONG Hong-bin, ZHANG Qin, HE Hui-yu, et al. Empirical Study of Reparation of Periodontal Bone Defects Treated with PRP and Calcined Bone Composite.[J]. Journal of Oral Science Research, 2015, 31(4): 332-335.

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