Role of RANK-RANKL-OPG Signaling Pathway in Bone Remodeling

doi:10.13701/j.cnki.kqyxyj.2016.06.027

Abstract

Abstract: Bone is a dynamic organization which sustains its balance and structural integrity through bone remodeling that composed of bone resorption and bone formation. Receptor activator of nuclear factor kB (RANK)-receptor activator of nuclear factor kB ligand (RANKL)-osteoprotegerin (OPG) has major effects on bone remodeling, especially in the osteoblast lineage to regulate the differentiation and activity of osteoclasts. In addition, the further research of this pathway will have important guiding significance for the clinical treatment of osteoporosis and cardiovascular disease. This article aims to explain the RANK-RANKL-OPG signaling pathway's molecular mechanism in bone.

CLC Number:

R782.12

LI Xue, ZHOU Yan-min, MA Shan-shan, MA Yao, GUO Tian-qi, XU Zhao-nan.. Role of RANK-RANKL-OPG Signaling Pathway in Bone Remodeling[J]. Journal of Oral Science Research, 2016, 32(6): 659-671.

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