Expression and Roles of E-cadherin and Vimentin in Epithelium-mesenchymal Transition of Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2016.08.020

Abstract

Abstract: Objective: To investigate the expression and roles of E-cadherin and vimentin in epithelium- mesenchymal transition (EMT) of oral squamous cell carcinoma (OSCC). Methods: Seventy-six cases with OSCC and 40 healthy subjects as control group were involved. The expression of TGF-β1, E-cadherin and Vimentin were detected by RT-PCR. Results: The gene expression levels of TGF-β1 and Vimentin in the tissues of OSCC patients were significantly higher than healthy subjects, while the gene expression levels of E-cadherin was significantly lower (P<0.05). The expression levels of TGF-β1, E-cadherin and Vimentin were associated with the degree of cell differentiation in OSCC tissues. Pearson correlation analysis showed that the gene expression levels of TGF-β1 was negatively correlated with E-cadherin in OSCC (r=-0.322, P=0.004), but was positively correlated with Vimentin (r=0.661, P=0.000). Conclusion: The expression of TGF-β1 and Vimentin was up-regulated in OSCC, whereas the expression of E-cadherin was down-regulated, indicating that EMT plays an important role in the development of OSCC.

Key words: Oral squamous cell carcinoma, E-cadherin, Vimentin, TGF-β1

CLC Number:

R739.8

CHEN Zheng, GUO Yan. Expression and Roles of E-cadherin and Vimentin in Epithelium-mesenchymal Transition of Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2016, 32(8): 857-860.

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