Expression of Periostin in Oral Squamous Cell Carcinoma and Its Role in Epithehial-mesenchymal Transition.

doi:10.13701/j.cnki.kqyxyj.2017.03.007

Abstract

Abstract: Objective: To investigate the expression of Periostin in oral squamous cell carcinoma (OSCC) and explore its role in epithehial-mesenchymal transition (EMT). Methods: Immunohistochemistry was used to detect the expression of Periostin, E-cadherin and Vimentin in 59 cases of oral squamous cell carcinoma specimens and 15 cases of normal oral mucosa specimens. The relationship between Periostin expression and EMT was also analyzed. Results: The positive rate of Periostin, E-cadherin and Vimentin in the specimens of OSCC patients was 71.2%, 52.5% and 39.0%, respectively. And the expression of Periostin was significantly correlated with TNM stage, tumor differentiation degree and lymph node metastasis (P＜0.05). Also, Periostin expression was negatively correlated with E-cadherin expression and positively correlated with Vimentin expression (P＜0.01). Conclusion: Periostin may promote the invasion and metastasis of oral squamous cell carcinoma through regulating epithehial-mesenchymal transition.

Key words: Periostin , Oral squamous cell carcinoma, Epithehial-mesenchymal transition , Invasion , Metastasis

CLC Number:

R739.8

ZHANG Yang-an, GUAN Wei-qun, LI Qun, OU YANG Qi-ming. Expression of Periostin in Oral Squamous Cell Carcinoma and Its Role in Epithehial-mesenchymal Transition.[J]. Journal of Oral Science Research, 2017, 33(3): 262-265.

References

[1] 韩影,苏彤,林璐,等.口腔癌对侧颈淋巴结转移的临床研究[J].口腔医学研究,2016,32(2)∶154-157
[2] Planche A, Bacac M, Provero P, et al. Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer [J]. PloS One,2011,6(5)∶e-18640
[3] Hong L, Sun H, Lv X, et al. Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro [J]. Mol Biol Rep,2010,37(5)∶2285-2293
[4] Guarino M. Epithelial-mesenchymal transition and tumour invasion [J]. Int J Biochem Cell Biol,2007,39(12)∶2153-2160
[5] Krisanaprakornkit S, Iamaroon A. Epithelial-mesenchymal transition in oral squamous cell carcinoma [J]. ISRN O- ncol,2012,20(12)∶681469
[6] Zhou J, Tao D, Xu Q, et al. Expression of E-cadherin and vimentin in oral squamous cell carcinoma [J]. Int J Clin Exp Pathol,2015,8(3)∶3150-3154
[7] 陈震,郭燕.E-cadherin和Vimentin在OSCC上皮-间质转化中的作用及表达[J].口腔医学研究,2016,32(8)∶857-860
[8] Weng W, Yin J, Zhang Y, et al. Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin [J]. Int J Oncol,2014,44(3)∶812-818
[9] Banyard J, Bielenberg DR, et al. The role of EMT and MET in cancer dissemination [J]. Connect Tissue Res,2015,56(5)∶403-13
[10] Oskarsson T, Acharyya S, Zhang XH, et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs [J]. Nat Med,2011,17(7)∶867-874
[11] Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis [J]. Cancer Metastasis Rev, 2010, 29(2)∶295-307
[12] Ratajczak-Wielgomas K, Dzegiel P. The role of periostin in neoplastic processes [J]. Folia Histochem Cytobiol,2015,53(2)∶120-132
[13] Morra L, Rechsteiner M, Casagrande S, et al. Relevance of periostin splice variants in renal cell carcinoma [J]. The American journal of pathology,2011,179(3)∶1513-1521

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