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    28 July 2022, Volume 38 Issue 7 Previous Issue    Next Issue

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    Application of Saliva Biomarkers in Early Detection of Alzheimer's Disease
    MA Guowu, ZHAO Pengcheng
    2022, 38(7): 591-596.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.001
    Abstract ( 320 )   PDF (994KB) ( 442 )  
    Saliva contains many biomarkers, which are closely related to the occurrence, development, diagnosis, and treatment of oral and systemic diseases. The detection of biomarkers plays an important role in the early screening and diagnosis of Alzheimer's disease (AD). Because of its close connection with the nervous system, saliva is expected to become a library of AD-related biomarkers. This article introduces and evaluates the biomarkers in saliva that can be used for early detection of AD and the biosensors that can be used to detect these markers, in order to provide new ideas for the development of reliable AD saliva biomarkers and non-invasive biosensors.
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    Analysis of Factors Affecting the Success of Regenerative Endodontic Treatment
    CHENG Jing, SONG Guangtai
    2022, 38(7): 597-600.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.002
    Abstract ( 349 )   PDF (842KB) ( 424 )  
    Regenerative endodontic treatment may be considered as the first choice for the treatment of immature permanent necrotic teeth. The principle is to achieve tissue repair and pulp regeneration via cell homing with the advantage of continued root maturation, apical closure, and thickening of canal walls. Currently, the application of regenerative endodontic treatment in clinical practice has achieved preliminarily and showed excellent curative effect. However, there are lack of unified prognosis evaluation and analysis of factors affecting its success. The purpose of this article is to review the prognosis evaluation criteria and factors affecting the success of regenerative endodontic treatment.
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    Research Progress on the Relationship between Feeding Patterns and Risk of Malocclusion in Children
    DONG Yuan, LI Na
    2022, 38(7): 601-604.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.003
    Abstract ( 525 )   PDF (833KB) ( 509 )  
    Malocclusion refers to the deformity of teeth, jaw, and cranium facial caused by genetic and environmental factors in the process of growth and development, and its incidence rate is rising in China. By analyzing the relevant researches in recent years, this paper confirms that breastfeeding helps to reduce the formation of non-nutritional sucking habits, and speculates that breastfeeding for at least six months after birth can not only reduce the time of bottle feeding, but also prevent the formation of bad sucking habits, so as to reduce the risk of malocclusion in children. At the same time, the scientific basis and pathogenesis of feeding patterns and the risk of malocclusion in children are relatively scarce. More relevant researches are needed to explore this problem in the future.
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    Application of Stem Cells from Human Exfoliated Deciduous Teeth in the Treatment of Oral and Maxillofacial Diseases
    PAN Lu, LIANG Yan
    2022, 38(7): 605-608.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.004
    Abstract ( 215 )   PDF (842KB) ( 267 )  
    Stem cells from human exfoliated deciduous teeth (SHEDs), a kind of odontogenic mesenchymal stem cells characterized by easy acquisition and high expansion efficiency, can differentiate into a variety of cells, form different tissues, and secrete a range of functional cellular activity factors. They can also regulate immunity, resist apoptosis, and facilitate tissue repair and regeneration. With diversified and intense research, the potential of SHEDs in the treatment of refractory diseases has been established, and SHEDs are now considered as one of the promising seed cells in tissue engineering and stem cell therapy. This study aims to elaborate the biological characteristics and advantages of SHEDs, and discuss their use in oral-maxillofacial diseases and research progress.
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    Study on Relationship between Enamel Defects of Primary Teeth and Early Caries in Children
    GAO Yilin, MIAO Yu
    2022, 38(7): 609-612.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.005
    Abstract ( 211 )   PDF (825KB) ( 241 )  
    Developing defect of enamel is a common disease in clinical practice. It is the abnormal quality and quantity of enamel caused by the damage of enamel organ. The disease occurs in both primary teeth and permanent teeth. In recent years, more and more children's dentists have paid attention to this disease, which occurs during tooth eruption and can lead to early caries if left untreated. In this paper, we review the literatures on the relationship between enamel developing defect of primary teeth and early caries in recent 15 years, and summarize the diagnosis, cause, treatment, and prevention measures.
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    Application and Research Progress of Sonic Fill Resin for Primary Molars
    ZHANG Lingling, LV Changhai
    2022, 38(7): 613-615.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.006
    Abstract ( 281 )   PDF (807KB) ( 431 )  
    Sonic Fill resin is a recently popular high viscosity bulk resin, and is the only resin that increases fluidity by ultrasonic agitation. Its curing depth can reach 4-5mm, the marginal adaptability is excellent, and the operation time can be significantly reduced. It is more and more often used in the filling of dental caries in children.
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    Cathepsin C gene Mutations and Functional Analysis of A Chinese Papillon-Lefèvre Syndrome Family
    PENG Hailong, YANG Yuan, QIN Man
    2022, 38(7): 616-621.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.007
    Abstract ( 148 )   PDF (2145KB) ( 211 )  
    Objective: To investigate the mutational CTSC gene in two Chinese patients with Papillon-Lefèvre syndrome (PLS; OMIM 245000) and analyze the cathepsin C functions. Methods: Genomic DNA was respectively isolated from peripheral blood samples of the patients and their parents. The CTSC gene was extracted and direct sequencing. The protein structure predictive server I-TASSER was used to analyze the change of Cathepsin C structure. Leukocytes were isolated from the patients and their parents's whole blood. Leukocyte cathepsin C activity was measured. Results: A compound heterozygous mutations c.774 C>G and c.1033 T>A in the CTSC was detected in two patients. The c.1033 T>A mutation was a novel substitution. After analysis of cathepsin C protein's structure, compared with wild-type CTSC, the predictive protein's structure after c.774 C>G and c.1033 T>A mutations had no obvious change. Leukocyte cathepsin C activity of the two patients was lower than normal contrasts on an average of about 77%. The cathepsin C activity of their father and mother reduced about 23% and 63%, respectively. Conclusion: In this research, a compound heterozygous mutations (c.774 C>G and c.1033 T>A) of CTSC gene were identified in two patients. The c.1033 T>A mutation is first reported and this kind of compound heterozygous mutation leads to a decrease of cathepsin C activity, but the protein structures have no change.
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    Characteristics of Supernumerary Teeth in Maxillary Anterior Region among Children without Syndrome: A Radiographic Study
    ZHENG Jiajia, DING Meili, WU Jiaqi, CHEN Hu, LI Hong
    2022, 38(7): 622-627.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.008
    Abstract ( 193 )   PDF (1663KB) ( 320 )  
    Objective: To investigate the radiographic properties of supernumerary teeth(ST)in maxillary anterior region among children without syndrome. Methods: Pediatric patients (1-14 years old) with periapical or panoramic radiograph who visited our institution from 2016/9/1 to 2021/8/31 were included. The number, morphology, and orientation of ST were compared between different genders. Results: (1) 286 subjects were included, among which 219 were male (76.6%) and 67 were female (23.4%). (2) Of 203 single ST cases, the most common shape was conical, followed by supplemental and tuberculate type (89.7%, 9.9%, and 0.5%, respectively). Most of ST were in normal orientation, followed by inverted and horizontal orientation regarding the tooth axis (63.4%, 27.2%, and 9.4%, respectively). (3) Of 82 patients with double ST, 21 patients (25.61%) presented different morphology, 61 patients presented the same morphology, among which 42 were conical-shaped ST and 19 were supplemental shape. Forty-two patients presented different orientation of ST and 40 patients presented the same orientation for the double ST patients. Conclusion: Males were more affected with ST than females. Most patients presented a single ST in maxillary anterior region. The most commonly shape was conical and the most commonly orientation was normal. For patients who have double ST, there were a significant proportion of inconsistent shapes and orientations. There were no significant differences in morphology and orientation between gender.
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    Genetic Study of PITX2 Mutation Leading to Non-syndromic Tooth Agenesis
    ZHANG Qin, LIN Shiyi, ZHANG Tingting, WANG Huijuan, YE Yangyang, ZHANG Xiangyu
    2022, 38(7): 628-631.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.009
    Abstract ( 174 )   PDF (1267KB) ( 197 )  
    Objective: To study the genetic etiology of a patient with non-syndromic tooth agenesis (NSTA) in a family. Methods: Peripheral blood of the proband and family numbers was collected, and whole-exome sequencing technique and bioinformatics tools were used to detect and analyze variants separately. After identifying the candidate gene of the proband, the variant site was verified by Sanger sequencing. The secondary structure and three-dimensional(3D)model of the mutant protein were analyzed and compared with the wild type using Protean and I-TASSER software. Results: Both the proband and his mother carried the same novel heterozygous frameshift mutation (c.176delT, p.I59fsX149) in PITX2. This mutation altered homeodomain and OAR domain, which affected the activity of DNA binding and the ability to activate downstream genes. The prediction of secondary structure revealed a decrease in the number of α helices of the mutant protein, and 3D model showed significant spatial conformational changes. Conclusions: The PITX2 frameshift mutation (c.176delT) may be one of the causes of NSTA in the proband. Our study extends the mutation spectrum of PITX2, and provides clinical and genetic evidence for further exploration of the association between PITX2 and NSTA.
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    Clinical Analysis of Non-syndromic Congenital Permanent Canines Agenesis in Children
    QIU Fenfang, MENG Shan, HU Wenwen
    2022, 38(7): 632-635.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.010
    Abstract ( 190 )   PDF (812KB) ( 212 )  
    Objective: To investigate the incidence and clinical characteristics of congenital permanent canines agenesis, and to analyze their distribution and clinical feature. Methods: Congenital permanent canines agenesis were collected, as well as the location and number of canines agenesis were recorded. Results: The prevalence of congenital permanent canines agenesis was 0.51% (190/37086). The number of boys (110) was more than that of girls (80), but there was no statistical difference (P>0.05). One or two permanent canines agenesis accounted for 98.42%(187/190). The number of permanent canines agenesis in maxilla (244) was more than that in mandible (33), and the difference was statistically significant (P<0.01). The number of teeth in the left jaw (133) was slightly less than that in the right (144), and the difference was not statistically significant (P>0.05). Conclusion: The congenital permanent canine absence is occasionally happened in clinic. There was no difference between the genders. Most of the cases were 1-2 permanent canines absence, and the maxilla was more often happened than the mandible, however, no difference between the left and right sides.
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    Analysis of Dental Developmental Anomalies in Children Aged 3-12 in Wuhan
    LI Hui, DONG Shi, XU Qingan
    2022, 38(7): 636-639.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.011
    Abstract ( 211 )   PDF (1143KB) ( 316 )  
    Objective: To investigate the occurrence of dental developmental anomalies in children aged 3-12 in Wuhan. Methods: Children aged 3-12 who came to Wuhan First Stomatological Hospital from February 2021 to February 2022 were selected, and 2848 panoramic radiographs were finally included to record the dental developmental anomalies. Results: The prevalence rate of dental developmental anomalies was 11.20%, and there was no significant gender difference (P>0.05). Congenitally absent teeth was common (7.20%), especially in females (P<0.05), and mostly occurred in the mandibular anterior teeth. The prevalence of absent deciduous teeth accompanied with the absent inherited permanent teeth germ was 97.06%. Supernumerary teeth (4.00%) was considerably common in males (P<0.05), and occurred most frequently in the maxillary anterior region. Odontoma was rare (0.07%). The prevalence rate of fused teeth was 1.23%, including 25 cases of deciduous teeth fusion, all of which were the fusion of mandibular deciduous incisors and deciduous canines. The prevalence rate of deciduous tooth fusion with the absent inherited permanent teeth germ was 92.00%, which was common on one side. Conclusion: The prevalence of dental developmental anomalies in children is high, and early panoramic radiograph is important.
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    DNA Vaccine pVAX1-GbpA/GBD on Immunization of Rabbits by Different Methods
    LI Hu, GUAN Xiaoyan, LI Min, DONG Jingnan, XIAO Qianwen, BAI Guohui, WANG Mingwei, LIU Jianguo
    2022, 38(7): 640-646.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.012
    Abstract ( 152 )   PDF (2202KB) ( 494 )  
    Objective: To compare the immune effects of poly (lactic/glycolic acid)-polyethylene glycol-poly (lactic/glycolic acid) hydrogel sustained-release anti-caries gene vaccine pVAX1-GbpA/GBD through different immunization routes. Methods: The temperature-sensitive biodegradable hydrogel PLGA-PEG-PLGA was mixed with recombinant plasmid pVAX1-GbpA/GBD and blank control. Twenty-eight New Zealand rabbits were randomly divided into seven groups (4 in each group). Plasmid pVAX1-GbpA/GBD was applied through intramuscular injection, oral administration, subcutaneous injection, or intranasal drip to rabbits. The control groups were intramuscular injection of pVAX1, oral administration of pVAX1 and hydrogel, and intramuscular injection of saline. All rabbits were immunized three times. After the first-time immunity, these rabbits need interval one week to strengthen the immunity by the same dosage, and then interval two weeks to strengthen the immunity 2nd time. The antibody responses induced by the vaccines were detected by indirect ELISA method. And the expression of recombinant protein was detected by immunohistochemistry technique. Results: (1) After 2 weeks of immunization, the levels of specific IgA antibody and IgG antibody in the saliva of 4 groups with anti caries gene vaccine increased significantly (P<0.05). The IgA anti GTF antibody level reached the highest in the 6th week, and the IgA anti GTF antibody level in the oral administration group was higher than those in the other 6 groups in the 4th week. The level of IgA anti GTF antibody in the submandibular gland injection group was higher than those in the other 6 groups at 6 and 10 weeks. The levels of IgA anti GTF antibody in the oral administration group and submandibular gland injection group were higher than those in the other groups at 8 and 12 weeks (P<0.05), however, no significant difference between them (P>0.05). (2) The levels of specific IgA antibody and IgG antibody in the serum of caries prevention gene vaccine group increased significantly 2 weeks after immunization (P<0.05). The level of IgG anti GTF antibody in the oral administration group was higher than those in the other 6 groups at 3, 6, and 10 weeks (P<0.05). The level of IgG anti GTF antibody in the submandibular gland injection group was higher than those in the other 6 groups at 4 and 8 weeks (P<0.05). (3) Immunohistochemical staining showed that the positive expression of pvax1 gbpA/GBD target protein was observed in the immune sites of four groups of anti caries gene vaccine group. The staining of pvax1 gbpA/GBD protein was obvious and strongly expressed in the cytoplasm of epithelial cells in the small intestinal mucosa of oral vaccine group and in the cytoplasm of ductal region of submandibular gland injection group. Conclusion: Through 4 immunization ways, the hydrogel sustained-release pVAX1-GbpA/GBD vaccine can induce effective systemic and mucosal immune response and maintain long time. The antibody levels induced by oral administration and submandibular gland injection are better.
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    Demineralization and Remineralization of Deciduous Teeth in Simulated Oral Environment
    GAO Li, ZHANG Hui, WANG Rui, TAO Huiqian, LIU Ling, JIANG Wenjing, WANG Mengyao, LI Linlin, YAN Bo
    2022, 38(7): 647-649.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.013
    Abstract ( 183 )   PDF (1274KB) ( 294 )  
    Objective: To study demineralization and remineralization of deciduous teeth in a flowing device simulating oral environment. Methods: Forty enamel specimens were collected and randomly divided into four groups: Watson soda group, fresh orange group, Coca-Cola group, and artificial saliva group (control group). In each group, five specimens were fluorinated and another five were un-fluorinated. Dental demineralization and remineralization were performed by a flowing device. The surface structure of the enamel was observed by scanning electron microscopy (SEM). Results: Under electron microscope, the degree of mineral dissolution on the enamel surface was increased when the beverage pH decreased gradually. After fluoriding, demineralization was improved and deposits could be seen. Conclusion: The experiment successfully showed the demineralization of deciduous enamels by acidic beverage and the remineralization by Duraphat using a dynamic flowing device, which had ideal practical significance.
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    Evaluation of Effect of Oral Primary Prevention for Preschool Children in Shanghai Minhang District During 2017-2021
    TIAN Zhijuan, SHI Hongyan, HAN Xiangyong
    2022, 38(7): 650-653.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.014
    Abstract ( 174 )   PDF (840KB) ( 271 )  
    Objective: To understand the oral health status of preschool children in Minhang District during 2017-2021, to evaluate the effect of oral primary prevention, and to provide scientific reference for caries prevention. Methods: Forty public kindergartens in Minhang District were selected in 2017. From 2017 to 2021, oral examination, oral health education, fluoride varnish, and oral health status notification were carried out to obtain the oral health condition data of children and establish their personal oral health record. Results: During 2017-2021, the prevalence of caries and the mean dmft of children aged 3-5 increased with age (P<0.01). The prevalence of caries and the mean dmft of preschool children showed a downward trend from 2018 to 2020 (P<0.01) due to the effect of oral primary prevention. The caries filling rate of preschool children was low, which was less than 20% in 2021. Conclusion: For preschool children, the prevention and intervention of dental caries is the key, and oral primary prevention has a significant effect on dental caries prevention. Early filling of dental caries should be strengthened to improve the filling rate in preschool children.
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    Three-dimensional Finite Element Analysis of the Influence of Base Materials and Thickness on Stress Distribution of Mandibular Second Deciduous Molar Restored with Inlay
    CAI Changyu, FENG Na, YANG Yu'e
    2022, 38(7): 654-658.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.015
    Abstract ( 164 )   PDF (1863KB) ( 220 )  
    Objective: To analyze the influence of base material and its thickness on stress distribution of the mandibular second deciduous molar which repaired with inlay after root canal treatment by three-dimensional finite element analysis. Methods: A three-dimensional finite element model of mandibular second deciduous molar with mesial and occlusal defects was established by CBCT scanning, and the resin inlay was simulated for restoration. The experimental group selected three kinds of materials with increasing elastic modulus (light cure glass ionomer, flowable composite resin, and high strength glass ionomer) and three kinds of thicknesses (0.5 mm, 1.0 mm, and 1.5 mm) as the base. The control group was without base. By loading a force of 100 N in the axial and lateral directions (45°) respectively, the stress distribution of tooth and inlay was observed, and the stress concentration positions and the change of peak stress were compared. Results: When axial and lateral forces were loaded, (1) stress concentration position: the stress concentration positions of experimental group and control group were similar, the stress of the mandibular second deciduous molar was mainly concentrated on the neck with the largest in the mesial and lingual, and the stress of the inlay was mainly concentrated on the occlusal and mesial; (2) peak stress change: the peak stress of the tooth was decreased when the thickness and elastic modulus of the base material were increased. However, the peak stress of the inlay was firstly decreased and then increased with the increase of the thickness of base material. And the peak stress of inlay did not change significantly under axial loading but decreased under lateral loading with the increase of elastic modulus. Conclusion: Base material with high elastic modulus and suitable thickness is beneficial to alleviate the stress concentration of mandibular second deciduous molar and the resin inlay after root canal treatment.
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    Effects of Preheating on Marginal Microleakage of Resin Composite Filled Pit and Fissure Caries Measured with Intraoral Scanner
    YU Fan, LV Changhai, MA Xueting, FU Lilin, RAO Nanquan, LIU Bo
    2022, 38(7): 659-665.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.016
    Abstract ( 176 )   PDF (1985KB) ( 237 )  
    Objective: To explore the effect of preheating on the marginal microleakage of 3M Z350 XT universal resin in the treatment of dental caries with different widths with the assistance of intraoral scanner. Methods: Fifty-one human permanent molars were collected. The roots of teeth were cut off, and the crowns were split from mesial side to distal side, departing into buccal piece and lingual/palatal piece. One hundred and two samples were randomly divided into 6 groups (n=17). L-shaped cavities with different widths were prepared on samples to simulate natural pits and fissures [the length of cavity was (4.0±0.5) mm, the depth was 2 mm, and the widths were 1 mm, 1.6 mm, and 2 mm, respectively]. The mark was made on the bur before the preparation to determine the depth of the cavity, the different burs were used to roughly measure the width and length of the cavity during the preparation. After the completion, the cavities in three dimensions were measured by TRIOS digital scanner. Only qualified samples were selected. The width of cavities in group A1, A2, and A3 were filled with room temperature Z350 XT universal resin composite, and in group B1, B2 and B3 were filled with 60℃ Z350 XT universal resin composite. All the samples were subjected to thermocycling. Sixteen samples randomly selected from each group were used to dye in 1% methylene blue solution for 24 h and to detect the extent of marginal microleakage quantitatively, while other samples were used for SEM observation. Results: There was no significant differences in the width, length, and depth of the cavities between the room temperature and preheating groups when the cavity was the same width (P>0.05). There was no significant difference between the preheating and non-preheating groups when filling the 1 mm-wide cavity (P>0.05). When filling the 1.6 mm-wide cavity, the degree of microleakage in the preheating group was lower than that in the non-preheating group at both site 1 and site 2 (P<0.05). When filling the 2 mm-wide cavity, although there was no significant difference between the preheating and non-preheating groups at site 1 (P>0.05), the non-preheating group showed more microleakage values compared to the preheating group at site 2 (P>0.05). SEM observation showed that the bonding interface became more compact in the preheating groups compared to the non-preheating groups, when filling the cavities with 1.6 mm and 2 mm width. Conclusion: Digital intraoral scanner has certain advantages to precisely measure the cavities in three dimensional directions. Preheating technology can reduce the marginal microleakage of resin composite. For pit and fissure caries with the width equal to or narrower than 2 mm, 60℃ Z350 universal resin composite is more suitable for filling the cavities with 1.6-2 mm width, especially for the cavities with complex morphology.
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    Comparison of Dycal and Glass Ion Double Bottom and Dycal Single Bottom in the Treatment of Deep Caries in Proximal Surface of Deciduous Molars
    WANG Wei, CAO Yan
    2022, 38(7): 666-668.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.017
    Abstract ( 274 )   PDF (790KB) ( 1080 )  
    Objective: To observe the curative effect of Dycal and glass ion double bottom and Dycal single bottom in the treatment of deep caries in proximal surface of deciduous molars. Methods: A total of 100 patients with deep caries in the proximal surface of deciduous molars were randomly divided into groups. In the first group, Dycal calcium hydroxide substrate and glass ion sandwich substrate were used to enamel dentin boundary, and then, 3M composite resin was used to fill the enamel layer. In the second group, the enamel layer was filled with 3M resin layer after Dycal monolayer. Results: For deep caries in the proximal surface of deciduous molars, the success rate of Dycal and glass ion double substrate was higher than that of Dycal single substrate. The incidence of clinical symptoms and abscission rate were lower than that of the Dycal monolayer group. Conclusion: It is suggested to use Dycal and glass ion double bottom to treat deep caries in the proximal surface of deciduous molars.
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    Three-year Outcome of iRoot BP Plus Pulpotomy in Primary Molars: A Retrospective Study
    ZHONG Wanjin, LI Yuemei, CHEN Chanchan, CHANG Huihui, DING Guicong
    2022, 38(7): 669-672.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.018
    Abstract ( 255 )   PDF (1151KB) ( 528 )  
    Objective: To observe the three-year curative effect of iroot BP plus pulpotomy of primary molars and analyze the influencing factors. Methods: In the electronic medical record database of Shenzhen Children's Hospital, the treatment records of iroot BP plus pulpotomy for deep caries of primary molars in the Department of Stomatology from January to December 2018 were retrieved. The patients aged 7 years and below, with a follow-up period of not less than 3 years and complete medical records were collected, and the primary molars following pulpotomy with iroot BP plus for deep caries of the patients were selected as the research objects. According to AAPD clinical and imaging evaluation criteria, the treatment success rate was calculated and the influencing factors were analyzed. Results: Fifty-eight teeth were finally included. The 3-year success rate was 87.93% (51/58). There was no significant difference in the success rate among different gender, ages, tooth position, dentition, hemostasis time, and crown restoration method (P>0.05). Conclusion: iroot BP plus has good therapeutic effect in the 3-year follow-up period of pulpotomy of primary molars.
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    Dental Trauma in Children: A Retrospective Analysis of 246 Cases
    LI Ruimin, DUAN Li, YANG Yafeng, YAN Yamei, ZHANG Zhaomeng, DING Xiaoyan, LV Na
    2022, 38(7): 673-677.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.019
    Abstract ( 199 )   PDF (928KB) ( 370 )  
    Objective: To analyze the clinical data of dental trauma in children's primary and permanent teeth, describe the distribution of dental trauma in children, and provide reference for the treatment and prevention of dental trauma. Methods: A cross-sectional study method was used to retrospectively analyze the clinical data of 246 children with dental trauma (407 teeth) who visited the Department of Pediatric Dentistry of Stomatological Hospital in Ningxia in 2020. Results: The ratio of male to female in dental trauma was 2.04∶1.00, and the maxillary central incisors were the most likely to be involved. The number of affected teeth in each child was mostly 1-2. The incidence of dental trauma in children was high in autumn, and the peak age was 8-10 years old (P<0.05). Among the permanent teeth trauma, the most common injury type was simple tooth hard tissue and pulp injury (52.00%), and to the primary teeth was simple periodontal tissue injury (58.60%). The differences were significant (P<0.01). Conclusion: Dental trauma in children is more common in boys and aged 8-10 years, and occurs frequently in autumn. Maxillary anterior teeth are the most vulnerable. Permanent tooth trauma often damages tooth hard tissue and pulp, and primary tooth trauma often damages periodontal tissue. However, due to the lack of behavioral awareness of children's dental trauma for guardians, it is necessary to strengthen the relevant health education and improve the prevention awareness.
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    A Retrospective Study of the Prognosis of 68 Cases of Children with Permanent Tooth Trauma
    ZHANG Hui, JIANG Wenjing, WANG Mengyao, LI Linlin, YAN Bo, GAO Li
    2022, 38(7): 678-681.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.020
    Abstract ( 163 )   PDF (1039KB) ( 241 )  
    Objective: To retrospectively analyze the prognosis of 68 cases of children with permanent tooth trauma. Methods: A total of 116 permanent teeth from 68 children with trauma in the Department of Pediatric Dentistry of our hospital from 2019 to 2021 were selected. The clinical data of gender, age, preeminent tooth location, visiting time, and development period were analyzed. The patients were followed up for six months to evaluate the prognosis of the affected teeth, and the influencing factors were analyzed by univariate analysis and multivariate Logistic regression analysis. The negative prognosis was summarized. Results: The patients were mostly male with an average age of (8.93±1.28) years. The time of visiting and the type of periodontal tissue injury were correlated with the prognosis of affected teeth (P<0.05). Multivariate regression analysis showed that more than 24 hours of visit time was a risk factor for prognosis (P<0.05). 50% of affected teeth showed negative prognosis, and 36.21% of which had root resorption. Conclusion: The time of visit and the type of periodontal tissue injury are related to the prognosis. Timely and professional treatment should be accepted after trauma. At the same time, the publicity of tooth injury prevention should be strengthened to raise the level of public attention.
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    Clinical Study on Efficacy of Three Different Sedation Methods in Dental Treatment of Autistic Children
    YANG Ge, CHANG Huihui, CHEN Chanchan, DING Guicong
    2022, 38(7): 682-686.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.021
    Abstract ( 180 )   PDF (847KB) ( 308 )  
    Objective: To determine the effectiveness and safety of three different sedation methods on patients with autism spectrum disorder during dental treatment. Methods: Ninety-one autistic children were selected and randomly divided into three groups, i.e. group M1 (n=29), group M2 (n=33), and group MD (n=29). They received intramuscular midazolam in 0.2 mg/kg, 0.24 mg/kg, and 0.2 mg/kg with intranasal dexmedetomidine in 2 μg/kg for sedation, respectively. Sedation effectiveness was analyzed by behavioral rating scales. Telephone following-ups were performed 24 hours after treatment to record the side effects and parents' satisfaction. Results: Children's vital signs were stable and no severe complications occurred. The degree of sedation in group MD was the deepest (group M1 vs. group MD, P<0.001; group M2 vs. group MD, P=0.004; group M1 vs. Group M2, P=0.047). The sedation depth had no relationship with age, sex, treatment program, or history. The sedation success rates in three groups were 31.0% (group M1), 42.4% (group M2), and 65.5% (group MD), with a significant difference among them. There was no significant difference in the treatment completion rates among three groups. The satisfaction rates of parents were 86.2%, 90.9%, and 86.2%, which were higher than the acceptance rates before treatment. Conclusion: Intramuscular midazolam with or without intranasal dexmedetomidine was an effective sedation method in dental treatment of pediatric patients with autism spectrum disorder. Combination of intramuscular midazolam and intranasal dexmedetomidine was associated with the best sedation effectiveness and the highest sedation success rate but longest onset time, when compared to other two groups of intramuscular midazolam.
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    Efficacy Evaluation of Motivational Interviewing Technique in Children after Oral General Anesthesia
    HAO Pengxiang, WU Jing
    2022, 38(7): 687-690.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.022
    Abstract ( 198 )   PDF (807KB) ( 239 )  
    Objective: To compare two oral health management methods in improving the postoperative effect for children received DGA, and to study the possible influencing factors. Methods: A total of 130 children who received DGA treatment were selected and divided into two groups. The caries activity, the number of caries, and the oral hygiene habits were recorded before DGA, 1 month, 3 months, and 6 months after DGA. Results: Compared with preoperative, the caries risk and caries rate of re-examination in 1 month, 3 months, and 6 months were decreased, but the decrease was more obvious in the experimental group (P<0.05). During the 6-month follow-up, the risk of caries state was correlated with the number of caries (P<0.05). Risk factors showed that only eating sweets and beverages before going to bed and using dental floss were significantly associated with the recurrence of caries after DGA (P<0.05). Conclusion: Compared with traditional oral education, motivational interviewing technology has obvious advantages in reducing caries risk and caries rate after DGA, and it is worthy of further promotion in clinical practice.
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    Supernumerary Primary Molar and Permanent Tooth and Congenital Absence of Left Mandibular First Molar: A Case Report
    GAO Hong, LI Zhengchen, TANG Mingna
    2022, 38(7): 691-693.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.023
    Abstract ( 216 )   PDF (1665KB) ( 366 )  
    Supernumerary tooth and congenitally absent tooth are common clinical diseases with abnormal number of teeth. We report a rare case of supernumerary primary molar and permanent tooth and congenital absence of first molar in the left mandible.
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    Fragment Reattachment of Permanent Central Incisor after Complicated Crown-root Fractures Assisted by Flap Surgery: A Case Report
    LI Xinyi, SHE Rui, SHI Qimeng, LI Yanhong
    2022, 38(7): 694-695.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.024
    Abstract ( 248 )   PDF (1216KB) ( 589 )  
    Complicated crown-root fracture is a kind of severe traumatic tooth injury, and its fracture line is often located subgingival, which brings difficulties to the treatment. Combined with flap surgery, the broken line can be fully exposed, with clear vision, good moisture isolation effect, and other advantages. In this paper, we report a case of permanent central incisor with complicated crown-root fracture assisted by flap surgery, and summarize the indications, advantages, and disadvantages of the treatment methods for complicated crown-root fracture.
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    Congenital Hemifacial Hyperplasia:A Case Report
    ZHOU Ziye, WANG Junhui, GUO Mingzhu, WANG Xiaojing
    2022, 38(7): 696-697.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.025
    Abstract ( 213 )   PDF (1176KB) ( 282 )  
    Congenital hemifacial hyperplasia is a rare congenital deformity characterized by marked overdevelopment of soft and hard tissues of the hemifacial region. We report one case of congenital hemifacial hyperplasia, and review the relevant literatures.
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    Minimally Invasive Extraction of Embedded Supernumerary Teeth in Child's Mental Foramen Area: A Case Report
    ZHENG Linwei, ZHAO Jihong
    2022, 38(7): 698-700.  DOI: 10.13701/j.cnki.kqyxyj.2022.07.026
    Abstract ( 289 )   PDF (1936KB) ( 296 )  
    Embedded supernumerary teeth in the mental foramen area are rare in clinic. If the embedded supernumerary teeth in this area cause permanent tooth displacement or root resorption, affect orthodontics, form cysts, etc., they must be removed surgically. Extraction may lead to root injury of permanent tooth, pulp necrosis, mental nerve injury and other complications. This paper introduces a case of minimally invasive extraction of embedded supernumerary teeth in child's mental foramen area.
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