Effect of Periodontal Infection on APP and IL-6 Levels in Patients with Cerebral Infarction.

doi:10.13701/j.cnki.kqyxyj.2016.02.011

Abstract

Abstract: Objective: To study the changes of acute phase protein (APP) and interleukin-6 (IL-6) levels in patients with cerebral infarction and effect of systemic antibody response of periodontal infection on APP and IL-6 levels.Methods: Eighty-eight patients with acute cerebral infarction for the first time and forty healthy subjects were included in this study. The subjects were grouped into Pg-IgG antibody positive [Pg-IgG (+) ] group and Pg-IgG antibody negative [Pg-IgG(-)] group according to Porphyromonas gingivalis IgG (P.g-IgG) levels. Serum high-sensitivity C-reactive protein (Hs-CRP), fibrinogen (Fg) and IL-6 levels were detected by enzyme-linked immune sorbent assay method and automatic blood coagulation analyzer. Results: Hs-CRP, Fg and IL-6 were significantly higher in patients with acute cerebral infarction than healthy subjects. Hs-CRP and IL-6 were significantly higher in Pg-IgG (+) group than that in Pg-IgG (-) group. Hs-CRP and IL-6 were positively correlated with Pg-IgG. Conclusion: Periodontal Porphyromonas gingivalis infection may increase cerebral infarction risk by promoting the levels of Hs-CRP and IL-6.

CLC Number:

R781.4

ZHANG Zheng, ZHANG Li, ZHENG You-li, MA Ning.. Effect of Periodontal Infection on APP and IL-6 Levels in Patients with Cerebral Infarction.[J]. Journal of Oral Science Research, 2016, 32(2): 150-153.

References

[1] 张正,郑友丽,张莉,等.牙周炎与脑卒中危险性[J]. 口腔医学研究,2012,28(5)∶401-403
[2] Miyashita H, Honda T, Maekawa T, et al. Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis[J]. Arch Oral Biol, 2012, 57(6)∶820-829
[3] Pussinen PJ, Kononen E, Paju S, et al. Periodontal pathogen carriage, rather than periodontitis, determines the serum antibody levels[J]. J Clin Periodontol, 2011, 38(5)∶405-411
[4] Vilkuna-Rautiainen T, Pussinen PJ, Roivainen M, et al. Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease[J]. Int J Epidemiol, 2006, 35(6)∶1486-1494
[5] Sakai Y, Shimauchi H, Ito HO, et al. Porphyromonas gingivalis-specific IgG subclass antibody levels as immunological risk indicators of periodontal bone loss[J]. J Clin Periodontol, 2001, 28(9)∶853-859
[6] Kitamura A, Iso H, Imano H, et al. Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men[J]. Stroke, 2004, 35(12)∶2788-2794
[7] Koenig W, Khuseyinova N, Lowel H, et al. Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany[J]. Circulation, 2004, 110(14)∶1903-1908
[8] Bots ML, Elwood PC, Salonen JT, et al. Level of fibrinogen and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe[J]. J Epidemiol Community Health, 2002, 56(1)∶ i14-18
[9] Spada RS, Toscano G, Chiarenza S, et al. Ischemic stroke and fibrinogen in the elderly[J]. Arch Gerontol Geriatr Suppl, 2004, (9)∶403-406
[10] Woods A, Brull DJ, Humphries SE, et al. Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6[J]. Eur Heart J, 2000, 21(19)∶1574-1583
[11] Higashi Y, Goto C, Hidaka T, et al. Oral infection-inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease[J]. Atherosclerosis, 2009, 206(2)∶604-610
[12] Rahmati MA, Craig RG, Homel P, et al. Serum markers of periodontal disease status and inflammation in hemodialysis patients[J]. Am J Kidney Dis, 2002, 40(5)∶983-989
[13] Sahingur SE, Sharma A, Genco RJ, et al. Association of increased levels of fibrinogen and the -455G/A fibrinogen gene polymorphism with chronic periodontitis[J]. J Periodontol, 2003, 74(3)∶329-337
[14] Dye BA, Choudhary K, Shea S, et al. Serum antibodies to periodontal pathogens and markers of systemic inflammation[J]. J Clin Periodontol, 2005, 32(12)∶1189-1199

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