Progress of Exosomal MicroRNAs in Oral Squamous Cell Carcinoma

doi:10.13701/j.cnki.kqyxyj.2024.10.002

Abstract

Abstract: As an extracellular vesicle (EVs), exosomes have been identified as important mediators involved in intercellular communication in multiple studies. In neoplastic diseases, exosomes shed cells in the tumor microenvironment can carry abnormal amounts of proteins, nucleic acids, and some other cargos, internalized by other cells to regulate the signaling pathways in it, which in turn affect the development of tumors. Currently, exosomes microRNAs, as biomarkers of tumor diagnosis and prognostic, are widely concerned. Meanwhile, targeting exosomes as carriers to deliver microRNAs for tumor treatment is also one of the research hotpots. Here, we focus on the exosome microRNAs, review the mechanism of exosomes microRNAs in the occurrence and development of oral squamous cell carcinoma (OSCC), and summarize their application as a potential molecular biomarkers in disease diagnosis and targeted therapy.

Key words: exosome, microRNA, oral squamous cell carcinoma

WANG Jing, XU Wenhua. Progress of Exosomal MicroRNAs in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2024, 40(10): 855-860.

References

[1] Doyle LM, Wang MZ. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis[J]. Cells, 2019, 8(7): 727-751.
[2] Krylova SV, Feng D. The machinery of exosomes: Biogenesis, release, and uptake[J]. Int J Mol Sci, 2023, 24(2): 1337-1352.
[3] Wang J, Yang L. The role of exosomes in central nervous system tissue regeneration and repair[J]. Biomed Mater, 2023, 18(5): 10-28.
[4] Ma L, Li C, Yin H, et al. The mechanism of DNA methylation and miRNA in breast cancer[J]. Int J Mol Sci, 2023, 24(11): 9360-9376.
[5] Deng J, Wu M. COX10-AS1-mediated miR-361-5p regulated cell invasion and migration by targeting SPRY1 in oral squamous cell carcinoma[J]. Am J Transl Res, 2023, 15(3): 2191-2206.
[6] Meldolesi J. Exosomes and ectosomes in intercellular communication[J]. Curr Biol, 2018, 28(8): R435-R444.
[7] Sakha S, Muramatsu T, Ueda K, et al. Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma[J]. Sci Rep, 2016, 6: 38750.
[8] Wang X, Zhu X, Zhao Y. Targeting miR-185-3p inhibits head and neck squamous cell carcinoma by modulating RAB25[J]. Front Oncol, 2021, 11: 721416.
[9] Baghy K, Ladányi A, Reszegi A, et al. Insights into the tumor microenvironment-components, functions and therapeutics[J]. Int J Mol Sci, 2023, 24(24):17536.
[10] Li YY, Tao YW, Gao S, et al. Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p[J]. EBioMedicine, 2018, 36: 209-220.
[11] Wang WZ, Cao X, Bian L, et al. Analysis of mRNA-miRNA interaction network reveals the role of CAFs-derived exosomes in the immune regulation of oral squamous cell carcinoma[J]. BMC Cancer, 2023, 23(1): 591.
[12] Ye B, Duan Y, Zhou M, et al. Hypoxic tumor-derived exosomal miR-21 induces cancer-associated fibroblast activation to promote head and neck squamous cell carcinoma metastasis[J]. Cell Signal, 2023, 108: 110725.
[13] Wang B, Zhang S, Tong F, et al. HPV⁺ HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4[J]. Cancer Sci, 2022, 113(4): 1475-1487.
[14] He S, Zhang W, Li X, et al. Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation[J]. Bioengineered, 2021, 12(1): 2164-2174.
[15] Huang W, Zeng Z, Xu Y, et al. Investigating whether exosomal miR-205-5p derived from tongue squamous cell carcinoma cells stimulates the angiogenic activity of HUVECs by targeting AMOT[J]. Cancer Biomark, 2023, 38(2): 215-224.
[16] Wang Z, Jiao P, Zhong Y, et al. The endoplasmic reticulum-stressed head and neck squamous cell carcinoma cells induced exosomal miR-424-5p inhibits angiogenesis and migration of humanumbilical vein endothelial cells through LAMC1-mediated Wnt/β-catenin signaling pathway[J]. Cell Transplant, 2022, 31(3): 549-560.
[17] Capik O, Gumus R, Karatas OF. Hypoxia-induced tumor exosomes promote angiogenesis through miR-1825/TSC2/mTOR axis in oral squamous cell carcinoma[J]. Head Neck, 2023, 45(9):2259-2273.
[18] Chohan MH, Perry M, Laurance-Young P, et al. Prognostic role of CD68⁺ and CD163⁺ tumour-associated macrophages and PD-L1 expression in oral squamous cell carcinoma: A meta-analysis[J]. Br J Biomed Sci, 2023, 80: 11065.
[19] Momen-Heravi F, Bala S. Extracellular vesicles in oral squamous carcinoma carry oncogenic miRNA profile and reprogram monocytes via NF-κB pathway[J]. Oncotarget, 2018, 9(78): 34838-34854.
[20] Li M, Yang Y, Xiong L, et al. Metabolism, metabolites, and macrophages in cancer[J]. J Hematol Oncol, 2023, 16(1): 80.
[21] Cai J, Qiao B, Gao N, et al. Oral squamous cell carcinoma-derived exosomes promote M2 subtype macrophage polarization mediated by exosome-enclosed miR-29a-3p[J]. Am J Physiol Cell Physiol, 2019, 316(5): C731-C740.
[22] Tong F, Mao X, Zhang S, et al. HPV⁺ HNSCC-derived exosomal miR-9 induces macrophage M1 polarization and increases tumor radiosensitivity[J]. Cancer Lett, 2020, 478: 34-44.
[23] Li J, Bao Y, Peng S, et al. M2 macrophages-derived exosomal miRNA-23a-3p promotes the progression of oral squamous cell carcinoma by targeting PTEN[J]. Curr Issues Mol Biol, 2023, 45(6): 4936-4947.
[24] Wang K, Wang X, Pan Q, et al. Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation[J]. Mol Cancer, 2023, 22(1): 167.
[25] He T, Guo X, Li X, et al. Plasma-derived exosomal microRNA-130a serves as a noninvasive biomarker for diagnosis and prognosis of oral squamous cell carcinoma[J]. J Oncol, 2021, 2021:5547911.
[26] 邓威,孟颖,王晨星,等. miR-182在口腔鳞癌血清外泌体中的表达及其临床意义[J].南京医科大学学报(自然科学版),2021,41(4):509-515.
[27] Chen CM, Chu TH, Chou CC, et al. Exosome-derived microRNAs in oral squamous cell carcinomas impact disease prognosis[J]. Oral Oncol, 2021, 120:105402.
[28] He L, Ping F, Fan Z, et al. Salivary exosomal miR-24-3p serves as a potential detective biomarker for oral squamous cell carcinoma screening[J]. Biomed Pharmacother, 2020, 121:109553.
[29] Faur CI, Roman RC, Jurj A, et al. Salivary exosomal microRNA-486-5p and microRNA-10b-5p in oral and oropharyngeal squamous cell carcinoma[J]. Medicina (Kaunas), 2022, 58(10): 1478.
[30] Patel A, Patel S, Patel P, et al. Salivary exosomal miRNA-1307-5p predicts disease aggressiveness and poor prognosis in oral squamous cell carcinoma patients[J]. Int J Mol Sci, 2022, 23(18): 10639.
[31] Patel A, Patel P, Mandlik D, et al. A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma[J]. Biomark Res, 2023, 11(1): 64.
[32] Deng W, Meng Y, Wang B, et al. In vitro experimental study on the formation of microRNA-34a loaded exosomes and their inhibitory effect in oral squamous cell carcinoma[J]. Cell Cycle, 2022, 21(16): 1775-1783.
[33] Kirave P, Gondaliya P, Kulkarni B, et al. Exosome mediated miR-155 delivery confers cisplatin chemoresistance in oral cancer cells via epithelial-mesenchymal transition[J]. Oncotarget, 2020, 11(13): 1157-1171.
[34] Sayyed AA, Gondaliya P, Mali M, et al. MiR-155 inhibitor-laden exosomes reverse resistance to cisplatin in a 3D tumor spheroid and xenograft model of oral cancer[J]. Mol Pharm, 2021, 18(8): 3010-3025.
[35] Cui J, Wang H, Zhang X, et al. Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B[J]. Aging (Albany NY), 2020, 12(8): 6756-6773.
[36] Dickman CT, Lawson J, Jabalee J, et al. Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes[J]. Oncotarget, 2017, 8(9):15252-15266.