Role of All-trans Retinoic Acid in Osteogenic Differentiation.

doi:10.13701/j.cnki.kqyxyj.2018.10.002

Abstract

Abstract: All-trans retinoic acid (ATRA) can up-regulate osteoblast-related gene expression of many cells, such as bone marrow stromal cells and osteoblasts. Besides, it can promote mineralization of matrix. The use of this feature of ATRA can reduce bone resorption and promote bone formation in the clinic. However, high dose of ATRA inhibits osteogenic differentiation and promotes osteoclast differentiation, which is not conducive to the healing of bone defects. This study reviews the effects of ATRA on osteogenic differentiation of cells at home and abroad.

Key words: All-trans retinoic acid, Induced osteogenesis, Osteogenic differentiation

SHEN Chen-xi, BI Wen-juan.. Role of All-trans Retinoic Acid in Osteogenic Differentiation.[J]. Journal of Oral Science Research, 2018, 34(10): 1038-1041.

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